Palliative use of non-invasive ventilation in end-of-life patients with solid tumours: a randomised feasibility trial
Palliative use of non-invasive ventilation in end-of-life patients with solid tumours: a randomised feasibility trial
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DOI：
10.1016/s1470-2045(13)70009-3
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发表时间：
2013-03-01
期刊：
影响因子：
51.1
通讯作者：
Grassi, Mario
中科院分区：
文献类型：
--
作者：
Nava, Stefano;Ferrer, Miguel;Grassi, Mario
尽管有最好的医疗管理，许多晚期癌症患者仍会出现呼吸困难，特别是在生命的最后阶段。我们评估了无创机械通气（NIV）与氧气治疗的可接受性和有效性，在减少呼吸困难和阿片类药物的数量needing.Methods在这个随机可行性研究中，我们招募了来自七个中心在意大利，西班牙和台湾，谁有实体瘤和急性呼吸衰竭，并有一个预期寿命不到6个月的患者。我们随机分配患者接受NIV（使用压力支持模式，并根据患者的要求和面罩舒适度安排）或氧气治疗（使用文丘里或储液器面罩）。我们使用计算机生成的序列进行随机分组，根据患者的高碳酸血症状态（PaCO2 >45 mmHg或PaCO2
Background Despite best-possible medical management, many patients with end-stage cancer experience breathlessness, especially towards the end of their lives. We assessed the acceptability and effectiveness of non-invasive mechanical ventilation (NIV) versus oxygen therapy in decreasing dyspnoea and the amount of opiates needed.Methods In this randomised feasibility study, we recruited patients from seven centres in Italy, Spain, and Taiwan, who had solid tumours and acute respiratory failure and had a life expectancy of less than 6 months. We randomly allocated patients to receive either NIV (using the Pressure Support mode and scheduled on patients' request and mask comfort) or oxygen therapy (using a Venturi or a reservoir mask). We used a computer-generated sequence for randomisation, stratified on the basis of patients' hypercapnic status (PaCO2 >45 mm Hg or PaCO2