Primary pulmonary chondrosarcomas: a clinicopathologic study of 4 cases
Primary pulmonary chondrosarcomas: a clinicopathologic study of 4 cases
复制标题
DOI：
10.1016/j.humpath.2011.01.009
复制
发表时间：
2011-11-01
期刊：
影响因子：
3.3
通讯作者：
Moran, Cesar A.
中科院分区：
文献类型：
--
作者：
Kalhor, Neda;Suster, Saul;Moran, Cesar A.
肺的恶性软骨肿瘤是不常见的，虽然它们的发生在某些情况下，在文献中已报告，它们与其他良性软骨肿瘤的肺分离可能是非常困难的。本文报告四例原发性肺软骨肉瘤。患者为2名男性和2名女性，年龄在51至69岁之间。临床上最常见的症状是胸痛、呼吸困难和咳嗽。2例肿瘤位于中心，2例肿瘤位于周围。所有患者均完成了完整的手术切除。组织学上，2例肿瘤为低度透明型，而2例肿瘤主要为粘液样软骨肉瘤。在2例粘液样软骨肉瘤中，角蛋白、结蛋白、平滑肌肌动蛋白和CD 31的免疫组化染色均为阴性，而S-100蛋白在两例中均呈局灶性阳性染色。随访显示，1例低度恶性肿瘤患者在36个月时存活良好，而1例粘液样软骨肉瘤患者在诊断后45天因手术并发症死亡。另外2例患者失访。我们的研究强调了软骨肉瘤的普遍分布和这些肿瘤发生在肺时可能显示的组织病理学谱。(C)2011 Elsevier Inc. All rights reserved.
Malignant cartilaginous tumors of the lung are unusual, and although their occurrence has been reported in the literature in some cases, their separation from other benign cartilaginous tumors of the lung can be very difficult. Four cases of primary chondrosarcomas of the lung are presented. The patients are 2 men and 2 women between the ages of 51 and 69 years. Clinically, the most common symptoms were chest pain, dyspnea, and cough. Two tumors were centrally located, whereas 2 tumors were peripheral. Complete surgical resection was accomplished in all the patients. Histologically, 2 tumors were low grade of the hyaline type, whereas 2 tumors were predominantly myxoid chondrosarcomas. In the 2 myxoid chondrosarcomas immunohistochemical studies for keratin, desmin, smooth muscle actin, and CD31 were negative, whereas S-100 protein shows focal positive staining in both cases. Follow-up showed that one patient with low-grade tumor was alive and well at 36 months, whereas one patient with myxoid chondrosarcoma died 45 days after diagnosis because of surgical complications. Two additional patients were lost to follow-up. Our study highlights the ubiquitous distribution of chondrosarcomas and the histopathologic spectrum that these tumors may show when occurring in the lung. (C) 2011 Elsevier Inc. All rights reserved.