Eicosanoids seasonally impact pulmonary function in asthmatic patients with Japanese cedar pollinosis
Eicosanoids seasonally impact pulmonary function in asthmatic patients with Japanese cedar pollinosis
复制标题
类二十烷酸季节性影响患有日本雪松花粉病的哮喘患者的肺功能
DOI：
10.1016/j.alit.2020.04.014
复制
发表时间：
2020
影响因子：
6.8
通讯作者：
Nagata M.
中科院分区：
文献类型：
--
作者：
Soma T;Uchida Y;Nakagome K;Hoshi R;Nagata M.
背景资料：在日本雪松花粉（JCP）季节期间，哮喘和伴随的季节性过敏性鼻炎（SAR）患者的哮喘状况恶化。然而，潜在的mechanisms仍然不清楚。方法：我们分析了季节性变化的类花生酸水平在气道的哮喘患者和伴随SAR致敏JCP（N= 29，BA-SAR-JCP组）和那些没有致敏（N= 13，BA-AR-非JCP组）在JCP季节。评估类花生酸浓度变化与肺功能之间的相关性。收集呼出气冷凝液（EBC），并在JCP和非JCP季节进行肺功能检查。半胱氨酰白三烯（CysLT）、血栓素B 2（TXB 2）、前列腺素D2-甲肟用酶联免疫吸附法测定EBC中前列腺素D2-MOX（PGD 2-MOX）和白三烯B 4（LTB 4）的水平。与非JCP季节相比，在JCP季节期间BA-SAR-JCP组的log CysLT水平显著增加（分别为1.78±0.55，1.39±0.63 pg/mL，平均值±标准差，p= 0.01）和在JCP季节期间BA-AR-非JCP组中的那些（1.39±0.38 pg/mL，p= 0.04）。此外，TXB 2的对数水平似乎增加.然而，log LTB 4和log PGD 2-MOX水平没有增加。BA-SAR-JCP组两个季节CysLT对数值的变化与一秒用力呼气量（FEV 1）呈负相关（r=-0.52，p < 0.01）。结论：在BA-SAR-JCP组中，尽管进行了最佳的维持治疗，但气道中类花生酸水平的季节性增加可能会促进肺功能的恶化。
Background: Condition of asthma in patients with asthma and concomitant seasonal allergic rhinitis (SAR) deteriorates during the Japanese cedar pollen (JCP) season. However, the underlying mechanisms remain unclear.Methods: We analyzed seasonal variations in eicosanoid levels in the airways of patients with asthma and concomitant SAR sensitized to JCP (N= 29, BA-SAR-JCP group) and those not sensitized (N= 13, BA-AR-non-JCP group) during the JCP season. The association between changes in eicosanoid concentrations and pulmonary function was assessed. Exhaled breath condensate (EBC) was collected, and pulmonary function tests were performed during the JCP and non-JCP seasons. The cysteinyl leukotriene (CysLT), thromboxane B 2 (TXB 2), prostaglandin D 2-methoxime (PGD 2-MOX), and leukotriene B 4 (LTB 4) levels in the collected EBC were measured via enzyme-linked immunosorbent immunoassays.Results: The log CysLT levels significantly increased in the BA-SAR-JCP group during the JCP season compared with the non-JCP season (1.78±0.55, 1.39±0.63 pg/mL, mean±standard deviation, respectively, p= 0.01) and those in the BA-AR-non-JCP group during the JCP season (1.39±0.38 pg/mL, p= 0.04). Moreover, the log TXB 2 levels seemed to increase. However, the log LTB 4 and log PGD 2-MOX levels did not increase. The changes in the log CysLT levels during the two seasons were negatively correlated to forced expiratory volume in one second (FEV 1) in the BA-SAR-JCP group (r=-0.52, p< 0.01).Conclusions: In the BA-SAR-JCP group, seasonal increases in eicosanoid levels in the airway likely promoted deterioration in pulmonary function despite optimal maintenance treatment.