Association of television viewing with fasting and 2-h postchallenge plasma glucose levels in adults without diagnosed diabetes
Association of television viewing with fasting and 2-h postchallenge plasma glucose levels in adults without diagnosed diabetes
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DOI：
10.2337/dc06-1996
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发表时间：
2007-03-01
期刊：
影响因子：
16.2
通讯作者：
Owen, Neville
中科院分区：
文献类型：
--
作者：
Dunstan, David W.;Salmon, Jo;Owen, Neville
目的 - 我们检查了澳大利亚成年人看电视时间与空腹血糖 (FPG) 和 2 小时后血糖 (2-h PG) 水平的关系。 研究设计和方法 - 共有 8,357 名年龄 > 35 岁、未诊断出糖尿病并参加了一项基于人群的横断面研究（澳大利亚糖尿病、肥胖和生活方式研究 [AusDiab]）的成年人进行了研究评价。 FPG 和 2 小时 PG 的测量值通过口服葡萄糖耐量试验获得。使用访谈者填写的问卷评估自我报告的电视观看时间（前一周）。根据空腹血糖和胰岛素浓度计算胰岛素敏感性 (HOMA-%S) 和 β 细胞功能 (HOMA-%B) 的稳态模型评估 (HOMA)。 结果 - 在调整混杂因素和体力活动时间后，女性看电视的时间与 2 小时 PG、空腹胰岛素日志和 HOMA-%B 日志呈正相关，与 HOMA-%S 日志 (P < 0.05) 呈负相关，但与 FPG 无关。未观察到与男性血糖测量值存在显着相关性。女性 2 小时 PG 中每天平均看电视时间类别（< 1.0、1.0-1.9、2.0-2.91、3.0-3.91 和 >= 4.0）的 β 系数分别为 0（参考）、0.009、0.047、0.473 和 0.501（趋势 P = 0.02).结论-我们的研究结果强调了久坐行为（以电视观看时间表示）和血糖测量之间独特的有害关系，与体力活动时间和肥胖状况无关。这些关系根据性别和血糖测量类型的不同而有所不同，其中 2 小时 PG 测量与电视观看的相关性更强。研究结果表明，减少久坐行为对于预防 2 型糖尿病和心血管疾病（尤其是女性）具有重要作用。
OBJECTIVE - We examined the associations of television viewing time with fasting plasma glucose (FPG) and 2-h postchallenge plasma glucose (2-h PG) levels in Australian adults.RESEARCH DESIGN AND METHODS - A total of 8,357 adults aged > 35 years who were free from diagnosed diabetes and who attended a population-based cross-sectional study (Australian Diabetes, Obesity and Lifestyle Study [AusDiab]) were evaluated. Measures of FPG and 2-h PG were obtained from an oral glucose tolerance test. Self-reported television viewing time (in the previous week) was assessed using an interviewer-administered questionnaire. Homeostasis model assessment (HOMA) of insulin sensitivity (HOMA-%S) and beta-cell function (HOMA-%B) were calculated based on fasting glucose and insulin concentrations.RESULTS - After adjustment for confounders and physical activity time, time spent watching television in women was positively associated with 2-h PG, log fasting insulin, and log HOMA-%B and inversely associated with log HOMA-%S (P < 0.05) but not with FPG. No significant associations were observed with glycemic measures in men. The beta-coefficients across categories of average hours spent watching television per day (< 1.0, 1.0-1.9, 2.0-2.91 3.0-3.91 and >= 4.0) for 2-h PG in women were 0 (reference), 0.009, 0.047, 0.473, and 0.501, respectively (P for trend = 0.02).CONCLUSIONS - Our findings highlight the unique deleterious relationship of sedentary behavior (indicated by television viewing time) and glycemic measures independent of physical activity time and adiposity status. These relationships differed according to sex and type of glucose measurement, with the 2-h PG measure being more strongly associated with television viewing. The findings suggest an important role for reducing sedentary behavior in the prevention of type 2 diabetes and cardiovascular disease, especially in women.