The repertoires of circulating human CD8+ central and effector memory T cell subsets are largely distinct
The repertoires of circulating human CD8+ central and effector memory T cell subsets are largely distinct
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DOI：
10.1016/s1074-7613(03)00020-7
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发表时间：
2003-02-01
期刊：
影响因子：
32.4
通讯作者：
Pannetier, C
中科院分区：
文献类型：
--
作者：
Baron, V;Bouneaud, C;Pannetier, C
Memory T cells are divided into central and effector subsets with distinct functions and homing capabilities. We analyzed the composition and dynamics of the CD8(+) T cell repertoire of these subsets within the peripheral blood of four healthy individuals. Both subsets had largely distinct and autonomous TCRbeta repertoires. Their composition remained stable over a 9 month period, during which no cell passage between these subsets was detected despite important size variation of several clones. In one donor, four out of six TCRbeta clonotypes specific for the influenza A virus were detected in the central subset only, while the two others were shared. Altogether, these observations suggest that most effector memory T cells may not have derived from the central memory subset.
