Hypertension in patients with coronavirus disease 2019 (COVID-19): a pooled analysis
Hypertension in patients with coronavirus disease 2019 (COVID-19): a pooled analysis
复制标题
DOI：
10.20452/pamw.15272
复制
发表时间：
2020-04-30
影响因子：
4.8
通讯作者：
Henry, Brandon M.
中科院分区：
文献类型：
--
作者：
Lippi, Giuseppe;Wong, Johnny;Henry, Brandon M.
引言随着2019年冠状病毒病（COVID-19）的爆发得到认可，应确定该疾病严重或致命病程的临床预测因素，以实现风险分层并优化分配有限的资源。高血压已被广泛报道与疾病严重程度增加有关;然而，一些研究报告了不同的结果。结论该研究旨在评估高血压与严重和致命的COVID-1 9之间的关系。方法Scopus，Medline，和Web of Science数据库进行检索，以确定报告高血压患者在诊断为重度或非重度COVID的人群中的比例的研究。19或COVID-19幸存者和非幸存者。将获得的数据汇总到荟萃分析中，计算比值比（OR）和95%CIs.RESULTS高血压与严重COVID-19风险增加近2.5倍相关（OR，2.49; 95%CI，1.98-3.12; I-2 = 24%），以及具有类似显著较高的死亡风险（OR，2.42; 95%CI，1.51-3.90; I-2 = 0%）。在一项荟萃回归分析中，观察到重度COVID-19患者平均年龄增加与高血压和COVID-19严重程度的对数OR增加之间存在相关性（P = 0.03）。
INTRODUCTION As the outbreak of coronavirus disease 2019 (COVID-19) was recognized, the clinical predictors of severe or fatal course of the disease should be identified to enable risk stratification and to allocate limited resources optimally. Hypertension has been widely reported to be associated with increased disease severity; however, some studies reported different findings.OBJECTIVES The study aimed to evaluate the association between hypertension and severe and fatal COVID-1 9.METHODS The Scopus, Medline, and Web of Science databases were searched to identify studies reporting the rate of hypertensive patients in the population diagnosed with severe or nonsevere COVID-19 or in COVID-19 survivors and nonsurvivors. The obtained data were pooled into a meta-analysis to calculate odds ratios (ORs) with 95% CIs.RESULTS Hypertension was associated with a nearly 2.5-fold increased risk of severe COVID-19 (OR, 2.49; 95% CI, 1.98-3.12; I-2 = 24%), as well as with a similarly significant higher mortality risk (OR, 2.42; 95% CI, 1.51-3.90; I-2 = 0%). In a meta-regression analysis, a correlation was observed between an increase in the mean age of patients with severe COVID-19 and an increased log OR of hypertension and COVID-19 severity (P = 0.03).CONCLUSIONS This pooled analysis of the current literature would suggest that hypertension may be associated with an up to 2.5-fold higher risk of severe or fatal COVID-19, especially in older individuals.