Effectiveness and safety of biodegradable Mg-Nd-Zn-Zr alloy screws for the treatment of medial malleolar fractures.
Effectiveness and safety of biodegradable Mg-Nd-Zn-Zr alloy screws for the treatment of medial malleolar fractures.
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可生物降解的Mg-Nd-Zn-Zr合金螺钉治疗内踝骨折的有效性和安全性
DOI：
10.1016/j.jot.2020.11.007
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发表时间：
2021-03
影响因子：
6.6
通讯作者：
Hao Y
中科院分区：
文献类型：
--
作者：
Xie K;Wang L;Guo Y;Zhao S;Yang Y;Dong D;Ding W;Dai K;Gong W;Yuan G;Hao Y
/目的：本研究旨在评价采用我们的专利Mg-Nd-Zn-Zr合金（简称Mg-Nd-Zn-Zr合金）治疗内踝骨折的有效性和安全性。JDBM）螺钉的临床应用，为进一步的临床应用提供依据。9例内踝骨折患者使用涂层JDBM螺钉进行治疗。所有患者均为闭合性损伤，无开放性骨折。术后进行X线片检查，以评价骨折愈合和JDBM螺钉降解情况。采用视觉模拟评分法（VAS）评价患者术后疼痛程度，采用美国足踝矫形协会（AOFAS）踝-后足评分系统评价患者术后踝关节功能。术后并发症，包括感染，内固定失败，畸形愈合，在随访期间仔细记录。平均随访时间为12.2 ± 4.9个月。术后，所有患者均获得了良好的内踝骨折对线，骨折愈合前无一例发生JDBM螺钉断裂。术后X线片显示JDBM螺钉随着植入时间的延长逐渐降解，术后12个月可观察到明显降解。末次随访时，患者的平均VAS评分为2.3 ± 1.9。AOFAS评分平均为90.4 ± 8.9，优良率为88.9%。所有患者均未发生感染、内固定失败、畸形愈合或其他并发症。涂层可降解JDBM螺钉治疗内踝骨折疗效确切，具有良好的临床推广前景。本研究结果表明，涂层生物可降解JDBM螺钉是一种可供选择的骨折内固定器械，具有良好的临床应用前景。
/Objective: This study aimed to evaluate the effectiveness and safety of treating medial malleolar fractures using our patented Mg-Nd-Zn-Zr alloy (abbr. JDBM) screws with Ca–P coating, in order to provide a solid basis for their further clinical translation. Nine patients with medial malleolar fractures were treated using coated JDBM screws. All patients had closed injuries, and none had open fractures. Postoperative radiography was performed to evaluate fracture healing and degradation of the JDBM screws. The visual analogue scale (VAS) was used to evaluate the degree of postoperative pain perceived by the patients, and the American Orthopedic Foot and Ankle Society (AOFAS) ankle-hindfoot scoring system was used to evaluate their postoperative ankle function. Postoperative complications, including infection, failure of internal fixation, and malunion, were carefully recorded during follow-up. The mean follow-up time was 12.2 ± 4.9 months. After the operation, all patients achieved good medial malleolar fracture alignment, and none of them experienced breakage of the JDBM screws before fracture healing. Postoperative radiography indicated JDBM screws gradually degradated with implantation time, and obvious degradation could be observed 12 months, postoperatively. At the final follow-up, the patients’ mean VAS score was 2.3 ± 1.9. The mean AOFAS score was 90.4 ± 8.9, with excellent or good rates of 88.9%. None of the patients experienced infection, failure of internal fixation, malunion, or other complications. Coated biodegradable JDBM screws are effective for the treatment of medial malleolar fractures, and have good prospects for further clinical translation in the future. The results of this study indicates coated biodegradable JDBM screw is an alternative internal fixation instrument for fracture treatment and has excellent prospects for clinical translation.
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影响因子：
3.9
作者：
Windhagen H;Radtke K;Weizbauer A;Diekmann J;Noll Y;Kreimeyer U;Schavan R;Stukenborg-Colsman C;Waizy H
通讯作者：
Waizy H
外源刺猬拮抗剂延迟，但不能防止年轻小鼠骨折愈合。
影响因子：
4.1
作者：
Liu X;McKenzie JA;Maschhoff CW;Gardner MJ;Silva MJ
通讯作者：
Silva MJ
影响因子：
--
作者：
LAUGEHANSEN, N
通讯作者：
LAUGEHANSEN, N
影响因子：
2.8
作者：
Plaass, Christian;Ettinger, Sarah;Windhagen, Henning
通讯作者：
Windhagen, Henning
影响因子：
2.7
作者：
KITAOKA, HB;ALEXANDER, IJ;SANDERS, M
通讯作者：
SANDERS, M