Surgical Treatment Is Recommended for Advanced Oral Squamous Cell Carcinoma
Surgical Treatment Is Recommended for Advanced Oral Squamous Cell Carcinoma
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DOI：
10.1620/tjem.223.17
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发表时间：
2011-01-01
影响因子：
2.2
通讯作者：
Kobayashi, Toshimitsu
中科院分区：
文献类型：
--
作者：
Ogawa, Takenori;Matsuura, Kazuto;Kobayashi, Toshimitsu
口腔鳞状细胞癌是日本最常见的头颈部癌症之一。虽然最近的报道显示非手术治疗晚期头颈部鳞状细胞癌(包括舌癌)取得了积极的效果，但除了舌癌外，还没有制定明确的口腔癌治疗策略。为了评估合适的治疗方法，我们对114例经病理诊断为鳞状细胞癌(不包括舌癌)的日本口腔癌患者进行了回顾性图表回顾。总的5年生存率为53%，疾病特异性5年生存率为61%。单因素和多因素分析显示，低分期(I、II或III)和非手术治疗分别是口腔鳞癌预后良好和不良的因素，其风险比分别为0.17(95%可信区间0.045~0.6，p=0.0061)和5.3%(95%可信区间2.7~11，p<0.05)。
Oral squamous cell carcinoma is one of the most frequent types of head and neck cancers in Japan. Although recent reports have shown positive results of non-surgical treatment for advanced head and neck squamous cell carcinoma, including tongue cancer, no clear treatment strategies have been established for oral cancers, except for tongue cancer. To assess appropriate therapies, we conducted a retrospective chart review of 114 Japanese patients with oral cancers that were pathologically diagnosed as squamous cell carcinoma, excluding tongue cancers. The overall and the disease specific 5-year survival rates were 53% and 61%, respectively. Univariate and multivariate analyses revealed a lower stage (I, II, or III) and non-surgical treatment as good and poor prognostic factors of oral squamous cell carcinoma, respectively, based on their hazard ratios of 0.17 (95% Cl 0.045-0.60, p = 0.0061) and 5.3 (95% Cl 2.7-11, p