Regulating animals with gene drive systems: lessons from the regulatory assessment of a genetically engineered mosquito
Regulating animals with gene drive systems: lessons from the regulatory assessment of a genetically engineered mosquito
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DOI：
10.1080/23299460.2017.1407912
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发表时间：
2018-01-01
影响因子：
3.9
通讯作者：
Kuzma, Jennifer
中科院分区：
文献类型：
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作者：
Meghani, Zahra;Kuzma, Jennifer
为了保护或抑制物种的目的，基因驱动技术具有巨大的潜力。从理论上讲，即使在生态系统中释放相对较少的具有基因驱动系统的动物，也可以将有益或有害的基因引入该物种的整个野生型种群。鉴于基因驱动可能对物种和生态系统产生深远影响，其使用是一个极具争议的问题。社区和群体对自然及其养护或维护有不同的信念，对通过基因工程消灭、取代或增强特定动物物种的生态安全也有不同的关切。出于所有这些原因，对昆虫和其他具有基因驱动系统的动物进行严格的调控至关重要。在本文中，我们考虑的问题，美国食品和药物管理局是否准备有效地监管昆虫和其他动物的基因驱动。
For the purposes of conservation or suppression of species, gene drive technology has significant potential. Theoretically speaking, with the release of even relatively few animals with gene drive systems in an ecosystem, beneficial or harmful genes could be introduced into the entire wild-type population of that species. Given the profound impact that gene drives could have on species and ecosystems, their use is a highly contentious issue. Communities and groups have differing beliefs about nature and its conservation or preservation, as well as concerns about the ecological safety of the eradication, replacement or enhancement of particular species of animals by means of genetic engineering. For all those reasons, the rigorous regulation of insects and other animals with gene drive systems is crucial. In this paper, we consider the question of whether the United States Food and Drug Administration is prepared to effectively regulate insects and other animals with gene drives.