Computational fluid dynamics-based study of possibility of generating pulsatile blood flow via a continuous-flow VAD
Computational fluid dynamics-based study of possibility of generating pulsatile blood flow via a continuous-flow VAD
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DOI：
10.1007/s11517-016-1523-8
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发表时间：
2017-01-01
影响因子：
3.2
通讯作者：
Ghalichi, Farzan
中科院分区：
文献类型：
--
作者：
Nammakie, Erfan;Niroomand-Oscuii, Hanieh;Ghalichi, Farzan
直到最近几年，如果不考虑心脏移植，挽救终末期心力衰竭患者的生命几乎是无法补救的。对健康器官的需求一直远远超过捐赠。然而，VAD技术的发展确实改变了这些患者的管理。目前，血泵设计为脉动流或连续流，每种都有其自身的问题和局限性。例如，脉动泵大多体积庞大，几乎不能用于儿童。另一方面，由连续流泵产生的流量与自然心脏的脉动流形成对比。在这个项目中，使用计算流体动力学，我们研究了通过连续流血泵产生脉动血流的可能性，通过调整泵的转速，具有两种不同的模式（正弦和梯形），这两种模式都是根据生理需求和自然心脏的血流波形提出和设置的。本研究的一个重要特征是将泵的出口压力设置为与心力衰竭患者的生理条件相似，并且由于这些轴流泵对出口压力敏感，因此其性能的结果更加安全可靠。我们的研究结果表明，一个正弦曲线的模式相比，一个梯形的有可能实现一个适当的脉动流，通过精确控制转速略有优势。
Until recent years, it was almost beyond remedy to save the life of end-stage heart failure patients without considering a heart transplant. This is while the need for healthy organs has always far exceeded donations. However, the evolution of VAD technology has certainly changed the management of these patients. Today, blood pumps are designed either pulsatile flow or continuous flow, each of which has its own concerns and limitations. For instance, pulsatile pumps are mostly voluminous and hardly can be used for children. On the other hand, the flow generated by continuous-flow pumps is in contrast with pulsatile flow of the natural heart. In this project, having used computational fluid dynamics, we studied the possibility of generating pulsatile blood flow via a continuous-flow blood pump by adjusting the rotational speed of the pump with two distinct patterns (sinusoidal and trapezoidal), both of which have been proposed and set based on physiological needs and blood flow waveform of the natural heart. An important feature of this study is setting the outlet pressure of the pump similar to the physiological conditions of a patient with heart failure, and since these axial pumps are sensitive to outlet pressures, more secure and reliable results of their performance are achieved. Our results show a slight superiority of a sinusoidal pattern compared to a trapezoidal one with the potential to achieve an adequate pulsatile flow by precisely controlling the rotational speed.