Electromigration of ions across the skin: determination and prediction of transport numbers.
Electromigration of ions across the skin: determination and prediction of transport numbers.
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DOI：
10.1002/jps.20561
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发表时间：
2006-03
影响因子：
3.8
通讯作者：
Blaise Mudry;Richard H. Guy;Richard H. Guy;M. Delgado-Charro
中科院分区：
文献类型：
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作者：
Blaise Mudry;Richard H. Guy;Richard H. Guy;M. Delgado-Charro
在离子导入中，穿过皮肤的电场诱导外源施加离子和内源存在离子的电迁移。该方法可用于通过消除外用制剂中的竞争共离子来显着改善药物递送，因为这最大化了药物携带的电流分数（即转运数）。在这项研究中，通过使用12种不同的离子组合（4个阳离子x 3个阴离子），研究了输运数对阳极和阴极离子性质的依赖性。阳离子迁移数(t（C+) (o)）是其固有迁移率的函数，并取决于阴极上单个阴离子的迁移率；而t(C+) (o)与反离子浓度无关。此外，获得的大量数据与先前为所谓的“单离子”情况开发的理论框架非常吻合。此外，皮肤中的离子迁移数与水溶液中的离子迁移数之间有很强的相关性，这很容易从离子迁移率的测量中估计出来。因此，从这里开发的框架来看，应该有可能建立一个预测工具，将理论与简单的实验相结合，以优化离子电泳给药。
In iontophoresis, an electric field across the skin induces electromigration of exogenously applied and endogenously present ions. The approach can be used to improve dramatically drug delivery by elimination of competing co-ions in the externally applied formulation, as this maximizes the fraction of current carried by (i.e., the transport number of) the drug. In this study, the dependence of the transport number on the nature of the ions present at the anode and cathode was examined using 12 different combinations of ions (4 cations x 3 anions). Cationic transport numbers (t(C+) (o)) were a function of their inherent mobilities and depended upon those of the single anion at the cathode; however, t(C+) (o) was independent of the counter-ion concentration. The extensive data obtained agreed well, furthermore, with a theoretical framework previously developed for this so-called "single-ion" situation. In addition, there was a strong correlation between ionic transport numbers in the skin and those in aqueous solution, which are easily estimated from measurements of ionic mobility. It follows that it should be possible, from the framework developed here, to establish a predictive tool, combining theory with simple experiments, for the optimization of iontophoretic drug delivery.