A novel delivery system dextran sulfate coated amphiphilic chitosan derivatives-based nanoliposome: Capacity to improve in vitro digestion stability of (−)-epigallocatechin gallate
A novel delivery system dextran sulfate coated amphiphilic chitosan derivatives-based nanoliposome: Capacity to improve in vitro digestion stability of (−)-epigallocatechin gallate
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DOI：
10.1016/j.foodres.2014.12.015
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发表时间：
2015-03
影响因子：
8.1
通讯作者：
Liqiang Zou;Shengfeng Peng;Wei Liu;Xing-yi Chen;Cheng-mei Liu
中科院分区：
文献类型：
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作者：
Liqiang Zou;Shengfeng Peng;Wei Liu;Xing-yi Chen;Cheng-mei Liu
通过静电作用将硫酸葡聚糖（DS）包覆在两亲性壳聚糖衍生物纳米脂质体（DCMC-NL）表面，制备了一种新型的给药系统。与DCMC-NL相比，DS包覆的DCMC-NL（DS-DCMC-NL）具有更大的平均粒径、更低的多分散性指数和更负的zeta电位。DS-DCMC-NL具有良好的体外消化稳定性，在胃肠道环境中粒径变化不明显，而DCMC-NL与模拟肠液（SIF）混合后立即形成沉淀。以表没食子儿茶素没食子酸酯（EGCG）为亲水性模型药物，将其包封于DS-DCMC-NL中，包封率高达90.8%。表没食子儿茶素没食子酸酯（EG-DS-DCMC-NL）具有较好的缓释性能。DS-DCMC-NL包埋可有效减缓SIF过程中EGCG的降解。本研究为EGCG的进一步应用提供了一种有前景的载体。
A novel delivery system was developed by coating dextran sulfate (DS) on the surface of amphiphilic chitosan derivative nanoliposome (DCMC-NL) through electrostatic interaction. DS coated DCMC-NL (DS-DCMC-NL) exhibited larger average particle size, lower polydispersity index, and more negative zeta potential, compared with DCMC-NL. DS-DCMC-NL exhibited goodin vitrodigestion stability, with no obvious variations on particle size under gastrointestinal tract environment, while DCMC-NL immediately formed sediment after being mixed with simulated intestinal fluid (SIF). EGCG as a hydrophilic model drug was encapsulated in DS-DCMC-NL, with a high encapsulation efficiency (90.8%). EGCG loaded DS-DCMC-NL (EG-DS-DCMC-NL) exhibited a relative good sustaining release property. The degradation of EGCG during SIF was effectively slowed by the encapsulation with DS-DCMC-NL. This study expects to provide a promising carrier for further application of EGCG.