Specific target-directed axonal outgrowth from transplanted embryonic rodent retinae into neonatal rat superior colliculus.
Specific target-directed axonal outgrowth from transplanted embryonic rodent retinae into neonatal rat superior colliculus.
复制标题
将胚胎啮齿动物视网膜移植到新生大鼠上丘中的特定目标定向轴突生长。
DOI：
10.1016/0006-8993(87)90402-1
复制
发表时间：
1987
期刊：
影响因子：
2.9
通讯作者：
Lund,RD
中科院分区：
文献类型：
--
作者：
Hankin,MH;Lund,RD
我们已经调查了是否有针对性的视网膜轴突的顶盖生长的证据，以及是否的表面的头端脑干是一个强制性的基板，通过移植胚胎小鼠视网膜的新生大鼠的大脑导水管的视神经轴突生长。这种视网膜发出轴突，轴突通过脑实质向背侧生长，通过沿着中线向背侧延伸，或通过脑实质沿背侧定向的放射状延伸路线到达上级丘的浅层。移植视网膜的早期生长模式的研究，以及来自类似放置的皮质移植物的轴突生长的比较研究表明，视网膜轴突的生长是靶向的和特定的视神经轴突。
We have investigated whether there is evidence of target-directed growth of retinal axons to the tectum, and whether the surface of the rostral brainstem is an obligatory substrate for growing optic axons by transplanting embryonic mouse retinae to the cerebral aqueduct of neonatal rats. Such retinae emit axons that grow dorsally through the brain parenchyma to reach the superficial layers of the superior colliculus either by running dorsally along the midline, or by following a dorsally directed, radially arching course through the brain parenchyma. Studies of the early outgrowth pattern from transplanted retinae, and comparison studies of the axonal outgrowth from similarly placed cortical grafts suggest that outgrowth of retinal axons is target-directed and specific to optic axons.