Exercise capacity in the Fontan circulation
Exercise capacity in the Fontan circulation
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DOI：
10.1017/s1047951113001649
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发表时间：
2013-12-01
影响因子：
1
通讯作者：
Paridon, Stephen M.
中科院分区：
文献类型：
--
作者：
Goldberg, David J.;Avitabile, Catherine M.;Paridon, Stephen M.
Fontan手术可以创造一个稳定的循环，从童年到成年早期。然而，肺下泵室的缺乏导致运动能力有限的生理学，并且从青春期开始随着年龄的增长而下降。运动能力的限制在运动的峰值水平时更明显，但在更适度的活动水平时仍然存在。运动损伤的根本原因与中枢心血管因素（氧输送）和外周因素（氧提取）有关。改善心脏前负荷和改善瘦肌肉质量的干预措施可能有助于提高运动能力，也许会改变进行性下降的“自然史”。
The Fontan operation can create a stable circulation from childhood through early adulthood. However, the absence of a sub-pulmonary pumping chamber leads to a physiology in which exercise capacity is limited and decreases with age starting in adolescence. The limitation in exercise capacity is more pronounced at peak levels of exercise, but is still present during more modest levels of activity. The underlying causes of exercise impairment relate to both central cardiovascular factors (oxygen delivery) and peripheral factors (oxygen extraction). Interventions to improve cardiac preload and to improve lean muscle mass may help to improve exercise capacity and, perhaps, will alter the "natural history'' of the progressive decline.