A ROLE FOR TNF DURING AFRICAN TRYPANOSOMIASIS - INVOLVEMENT IN PARASITE CONTROL, IMMUNOSUPPRESSION AND PATHOLOGY
A ROLE FOR TNF DURING AFRICAN TRYPANOSOMIASIS - INVOLVEMENT IN PARASITE CONTROL, IMMUNOSUPPRESSION AND PATHOLOGY
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DOI：
10.1016/s0923-2494(93)80082-a
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发表时间：
1993-06-01
期刊：
影响因子：
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通讯作者：
DEBAETSELIER, P
中科院分区：
文献类型：
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作者：
LUCAS, R;MAGEZ, S;DEBAETSELIER, P
本文认为，肿瘤坏死因子（TNF）和干扰素-γ (IFN-γ)在非洲人锥虫病中锥虫与宿主的关系中起关键作用。研究表明，这两种淋巴因子都是由锥虫成分引起的，IFN-γ可能为锥虫提供刺激信号，而TNF则发挥直接的锥虫作用。这两种淋巴因子都可能过度激活巨噬细胞，从而使这些细胞获得抑制性表型。这些抑制性巨噬细胞与IFN-γ一起抑制T淋巴细胞的增殖，导致免疫抑制的深度状态。由于这两种淋巴因子具有强大的炎症作用，TNF和IFN-γ可能直接参与中枢神经系统的炎症反应。研究还表明，巨噬细胞通过这两种淋巴因子的慢性激活可能导致其他与锥虫相关的病理，如贫血和睡眠逆转。
In this review article it is suggested that tumour necrosis factor (TNF) and interferon-γ (IFN-γ) play key roles in the trypanosome-host relationship during African human trypanosomiasis. It is shown that both lymphokines are elicited by trypanosome components, and that IFN-γ may provide a stimulatory signal for trypanosomes whereas TNF exerts a direct trypanocidal action. Both lymphokines may hyperactivate macrophages whereby these cells acquire a suppressive phenotype. These suppressive macrophages in conjunction with IFN-γ inhibit the proliferation of T lymphocytes, leading to a profound state of immunosuppression. Because of the potent inflammatory action of both lymphokines, TNF and IFN-γ may directly contribute to inflammatory reactions in the central nervous system. It is also suggested that chronic activation of macrophages through these two lymphokines may contribute to other trypanosome-associated pathology, such as anaemia and sleep reversal.