The Cancer Microbiome: Recent Highlights and Knowledge Gaps.
The Cancer Microbiome: Recent Highlights and Knowledge Gaps.
复制标题
DOI：
10.1158/2159-8290.cd-21-0324
复制
发表时间：
2021-10
期刊：
影响因子：
28.2
通讯作者：
Sears CL
中科院分区：
文献类型：
--
作者：
Knippel RJ;Drewes JL;Sears CL
人类微生物组的知识正在迅速扩展，可能是多种形式癌症的发生，进展和预后的关键因素。在这篇综述中，我们专注于最近的调查，以辨别推定的致病微生物物种和/或微生物组的组成和结构，目前与促癌和肿瘤发生在选定的身体部位。我们特别强调了胃肠道和非胃肠道癌症的形式，这些癌症具有显著的细菌关联和明确的实验证据，旨在为未来的实验和转化研究提供方向，以更清楚地了解微生物群影响癌症形成的多方面机制。
The knowledge of the human microbiome is rapidly expanding and likely a critical factor in the initiation, progression and prognosis of multiple forms of cancer. In this review, we focus on recent investigations to discern putative causative microbial species and/or the microbiome composition and structure currently associated with pro-carcinogenesis and tumorigenesis at select body sites. We specifically highlight forms of cancer, gastrointestinal and non-gastrointestinal, that have significant bacterial associations and well-defined experimental evidence with the aim to generate directions for future experimental and translational investigations to develop a clearer understanding of the multifaceted mechanisms by which microbiota impact cancer formation.