Secondary metabolites from the mycelia of the fungus Monascus pilosus BCRC 38072
Secondary metabolites from the mycelia of the fungus Monascus pilosus BCRC 38072
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DOI：
10.1248/cpb.56.394
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发表时间：
2008-03-01
影响因子：
1.7
通讯作者：
Yuan, Gwo-Fang
中科院分区：
文献类型：
--
作者：
Cheng, Ming-Jin;Wu, Ming-Der;Yuan, Gwo-Fang
从红曲霉 BCRC 38072 菌丝体 MeOH 提取物的 EtOAc 可溶部分中分离出三种新化合物，包括两种苯乙酸衍生物莫那匹罗辛 (1) 和单那匹吲哚 (2)，以及一种吡喃吲哚生物碱莫那吡喃吲哚 (3)。本研究还获得了 12 种已知化合物。通过ID和2D NMR光谱以及质谱阐明了结构。这是首次报道带有吲哚环的红曲霉代谢物。还在 TLC 自描和光谱分析中评估了所有分离株对 2,2-二苯基-1-三硝基苯肼基 (DPPH) 的清除特性。
Three new compounds, including two phenylacetic acid derivatives, monaspilosin (1) and monaspiloindole (2), and one pyranoindole alkaloid, monaspyranoindole (3), were isolated from the EtOAc-soluble fraction of the MeOH extract of the mycelia of Monascus pilosus BCRC 38072. Twelve known compounds were also obtained in this study. The structures were elucidated by ID and 2D NMR spectroscopy and mass spectrometry. This is the first report of Monascus metabolites with an indole ring. All isolates were also evaluated for their scavenging properties toward the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) in TLC autographic and spectroscopic assays.