E2F-1 functions in mice to promote apoptosis and suppress proliferation
E2F-1 functions in mice to promote apoptosis and suppress proliferation
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DOI：
10.1016/s0092-8674(00)81255-6
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发表时间：
1996-05-17
期刊：
影响因子：
64.5
通讯作者：
Greenberg, ME
中科院分区：
文献类型：
--
作者：
Field, SJ;Tsai, FY;Greenberg, ME
E2 F转录因子家族成员（E2 F-1-E2 F-5）被认为是真核生物中细胞周期进程的关键正调节因子，尽管单个E2 F的体内功能尚未阐明。产生了缺乏E2 F-1的小鼠，令人惊讶的是，这些小鼠正常发育和繁殖。然而，E2 F-1（-/-）小鼠表现出T淋巴细胞发育缺陷，导致由于胸腺细胞凋亡中的成熟阶段特异性缺陷而导致成熟T细胞过量。随着E2 F-1（-/-）小鼠年龄的增长，它们表现出以异常细胞增殖为标志的第二种表型。这些发现表明，虽然E2 F家族的某些成员可能正调控细胞周期进程，E2 F-1的功能，以调节细胞凋亡和抑制细胞增殖。
Members of the E2F transcription factor family (E2F-1-E2F-5) are believed to be critical positive regulators of cell cycle progression in eukaryotes although the in vivo functions of the individual E2Fs have not been elucidated. Mice were generated that lack E2F-1 and, surprisingly, these mice develop and reproduce normally. However, E2F-1(-/-) mice exhibit a defect in T lymphocyte development leading to an excess of mature T cells due to a maturation stage-specific defect in thymocyte apoptosis. As E2F-1(-/-) mice age they exhibit a second phenotype marked by aberrant cell proliferation. These findings suggest that while certain members of the E2F family may positively regulate cell cycle progression, E2F-1 functions to regulate apoptosis and to suppress cell proliferation.