Differential effects of cutaneous and deep application of inflammatory irritant on mechanoreceptive field properties of trigeminal brain stem nociceptive neurons.
Differential effects of cutaneous and deep application of inflammatory irritant on mechanoreceptive field properties of trigeminal brain stem nociceptive neurons.
复制标题
皮肤和深层应用炎症刺激物对三叉神经脑干伤害性神经元机械感受场特性的不同影响。
DOI：
10.1152/jn.1993.70.4.1704
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发表时间：
1993
影响因子：
2.5
通讯作者：
Hu,JW
中科院分区：
文献类型：
--
作者：
Yu,XM;Sessle,BJ;Hu,JW
1.本研究的目的是确定皮肤和深层刺激对三叉神经尾侧亚核记录的伤害性脑干神经元机械感受野(RF)特性是否存在不同的神经再生效应。2.在麻醉大鼠中，共有31个尾侧神经元被鉴定为接受会聚的皮肤和深层传入的伤害性神经元，并测试了小纤维刺激剂和炎性刺激性芥子油对其皮肤和深层RFs的影响。3.神经可塑性在神经元皮肤和深层的表达与该刺激物的作用部位有关。将芥子油注射到舌肌中，可显著且可逆地扩张皮肤和深层的RFs。相反，将芥子油应用于面部皮肤可导致皮肤射频显著且可逆的扩张，但没有发生深层射频扩张。4.这些结果表明，外周炎性刺激可以诱导V伤害性神经元皮肤和深层RF特性的相当大的功能性神经可塑性，并且深层输入在诱发这些神经可塑性变化方面尤其有效。
1. The aim of this study was to determine whether there are differential neuroplastic effects of cutaneous and deep stimuli on the mechanoreceptive field (RF) properties of nociceptive brain stem neurons recorded in trigeminal (V) subnucleus caudalis. 2. A total of 31 caudalis neurons were functionally identified in anesthetized rats as nociceptive neurons receiving convergent cutaneous and deep afferent inputs, and the effects of the small-fiber excitant and inflammatory irritant mustard oil applied to either tongue muscle or facial skin were tested on their cutaneous and deep RFs. 3. The expression of neuroplasticity on the cutaneous and deep RFs of the neurons was found to depend on the site of application of this irritant. Mustard oil injected into the tongue muscle produced a significant and reversible expansion of both the cutaneous and deep RFs. In contrast, application of mustard oil to facial skin resulted in a significant and reversible expansion of the cutaneous RF, but no deep RF expansion occurred. 4. These findings suggest that considerable functional neuroplasticity of the cutaneous and deep RF properties of V nociceptive neurons can be induced by a peripheral inflammatory irritant and that deep inputs are especially effective in evoking these neuroplastic changes.