Postnatal development of calcium-binding proteins immunoreactivity (parvalbumin, calbindin, calretinin) in the human entorhinal cortex
Postnatal development of calcium-binding proteins immunoreactivity (parvalbumin, calbindin, calretinin) in the human entorhinal cortex
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DOI：
10.1016/j.jchemneu.2003.09.005
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发表时间：
2003-12-01
影响因子：
2.8
通讯作者：
Insausti, R
中科院分区：
文献类型：
--
作者：
Grateron, L;Cebada-Sanchez, S;Insausti, R
内嗅皮层是人类海马结构组织中与皮层活动相关的重要组成部分。它传递新皮层信息（最终分布到齿状回和海马），并接收大部分定向到新皮层的海马输出。出生时，人类内嗅皮质呈现出与成人相似的分层组织，尽管第11层（细胞岛）和上层III的成熟时间较长。表达钙结合蛋白（小清蛋白、钙结合蛋白-D28 K（钙结合蛋白）和钙视网膜蛋白）的中间神经元的存在在成年人内嗅皮层中得到了充分的证明。在其中许多细胞中，钙结合与GABA共定位。Parvalbumin免疫反应细胞和纤维出生时几乎不存在，他们的存在逐渐增加，在深层III，主要是在外侧和尾侧部分的内嗅皮层从第5个月起。钙结合蛋白免疫反应阳性细胞和纤维出生时，主要在第二层和上III，主要是在喙和侧部的内嗅皮层，数量增加，并延伸到深层从第5个月起。出生时，Calretinin免疫反应性存在，均匀分布在I，II和上V层，整个内嗅皮质。在第5个月，观察到第V层的calretinin神经元的数量大幅增加。出生后发育的小清蛋白，钙结合蛋白和钙视网膜蛋白可能有一个重要的作用，通过控制海马，皮层和皮层下信息的内嗅皮层的功能成熟。(C)2003 Elsevier B. V.保留所有权利。
The entorhinal cortex is an essential component in the organization of the human hippocampal formation related to cortical activity. It transfers, neocortical information (ultimately distributed to the dentate gyrus and hippocampus) and receives most of the hippocampal output directed to neocortex. At birth, the human entorhinal cortex presents similar layer organization as in adults, although layer 11 (cell islands) and upper layer III have a protracted maturation. The presence of interneurons expressing calcium-binding proteins (parvalbumin, calbindin-D28K (calbindin) and calretinin) is well documented in the adult human entorhinal cortex. In many of them the calcium binding is co-localized with GABA. Parvalbumin-immunoreactive cells and fibers were virtually absent at birth, their presence increasing gradually in deep layer III, mostly in the lateral and caudal portions of the entorhinal cortex from the 5th month onwards. Calbindin immunoreactive cells and fibers were present at birth, mainly in layers II and upper III; mostly at rostral and lateral portions of the entorhinal cortex, increasing in number and extending to deep layers from the 5th month onwards. Calretinin immunoreactivity was present at birth, homogeneously distributed over layers I, II and upper V, throughout the entorhinal cortex. A substantial increase in the number of calretinin neurons in layer V was observed at the 5th month. The postnatal development of parvalbumin, calbindin and calretinin may have an important role in the functional maturation of the entorhinal cortex through the control of hippocampal, cortical and subcortical information. (C) 2003 Elsevier B.V. All rights reserved.