Mapping Human Somatosensory Cortex in Individual Subjects With 7T Functional MRI
Mapping Human Somatosensory Cortex in Individual Subjects With 7T Functional MRI
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DOI：
10.1152/jn.01017.2009
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发表时间：
2010-05-01
影响因子：
2.5
通讯作者：
Schluppeck, D.
中科院分区：
文献类型：
--
作者：
Sanchez-Panchuelo, R. M.;Francis, S.;Schluppeck, D.
杨文伟，王文伟，王文伟.用7 T功能MRI对个体受试者的躯体感觉皮层进行映射。J Neurophysiol 103：2544-2556，2010.首次发表于2010年2月17日; doi：10.1152/jn.01017.2009。功能性磁共振成像（fMRI）现在被常规用于绘制人类视觉皮层的地形组织。然而，绘制躯体感觉皮层的详细地形图已被证明是更加困难的。在这里，我们使用了增加的血氧水平依赖的对比度噪声比在超高场（7特斯拉），以测量在1毫米的各向同性分辨率在个体受试者的数字在人类体感皮层的地形表示。一个“行波”的范例被用来定位区域的皮层响应周期性的触觉刺激的每个远端指骨数字。触觉刺激从拇指到小指顺序地施加到左手的每个手指（以及以相反的顺序）。在所有的科目，我们发现了一个有序的地图上的中央沟（中央后回）的后银行的数字。此外，我们测量了事件相关的反应，以简短的刺激与地形图数据和相关的功能磁共振成像反应的解剖图像与反转恢复序列的比较。我们的研究结果具有重要的意义，人类躯体感觉皮层的研究，并强调了实际效用的超高场功能成像与1毫米各向同性分辨率的神经科学实验。首先，躯体感觉皮层的地形图可以在20分钟内完成，从而在同一会话中有时间进行进一步的实验。第二，地图是足够高的分辨率，以解决所有五个数字的表示和第三，测量是鲁棒的，可以在一个单独的主题。这些综合优势将允许躯体定位功能磁共振成像被用来测量周围神经损伤后进行康复或塑性变化的患者的手指的代表性，以及跟踪进行知觉学习的正常受试者的变化。
Sanchez-Panchuelo RM, Francis S, Bowtell R, Schluppeck D. Mapping human somatosensory cortex in individual subjects with 7T functional MRI. J Neurophysiol 103: 2544-2556, 2010. First published February 17, 2010; doi: 10.1152/jn.01017.2009. Functional magnetic resonance imaging (fMRI) is now routinely used to map the topographic organization of human visual cortex. Mapping the detailed topography of somatosensory cortex, however, has proven to be more difficult. Here we used the increased blood-oxygen-level-dependent contrast-to-noise ratio at ultra-high field (7 Tesla) to measure the topographic representation of the digits in human somatosensory cortex at 1 mm isotropic resolution in individual subjects. A "traveling wave" paradigm was used to locate regions of cortex responding to periodic tactile stimulation of each distal phalangeal digit. Tactile stimulation was applied sequentially to each digit of the left hand from thumb to little finger (and in the reverse order). In all subjects, we found an orderly map of the digits on the posterior bank of the central sulcus (postcentral gyrus). Additionally, we measured event-related responses to brief stimuli for comparison with the topographic mapping data and related the fMRI responses to anatomical images obtained with an inversion-recovery sequence. Our results have important implications for the study of human somatosensory cortex and underscore the practical utility of ultra-high field functional imaging with 1 mm isotropic resolution for neuroscience experiments. First, topographic mapping of somatosensory cortex can be achieved in 20 min, allowing time for further experiments in the same session. Second, the maps are of sufficiently high resolution to resolve the representations of all five digits and third, the measurements are robust and can be made in an individual subject. These combined advantages will allow somatotopic fMRI to be used to measure the representation of digits in patients undergoing rehabilitation or plastic changes after peripheral nerve damage as well as tracking changes in normal subjects undergoing perceptual learning.