Craniofacial findings in fibrodysplasia ossificans progressiva: computerized tomography evaluation
Craniofacial findings in fibrodysplasia ossificans progressiva: computerized tomography evaluation
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DOI：
10.1016/j.tripleo.2010.12.002
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发表时间：
2011-04-01
期刊：
影响因子：
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通讯作者：
Speck-Martins, Carlos Eduardo
中科院分区：
文献类型：
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作者：
Carvalho, Daniel Rocha;Farage, Luciano;Speck-Martins, Carlos Eduardo
Objective.本研究的目的是通过使用计算机断层扫描（CT）的颅面异常进行性骨化性纤维发育不良（FOP）患者有关颌限制和缩颌的评价。在这项观察性研究中，对7例FOP患者进行了回顾性评价。纳入标准为ACVR 1基因突变检测和完整的颅面CT检查。临床上确定了下颌受限的年龄和下颌后缩的存在。分析的特点是颅底结构和异位骨化（HO）。在该组（年龄范围4-23岁）中，3名年龄最大的患者表现为下颌受限和下颌后缩，并显示翼外板延长，翼肌HO达到右下颌支的内侧面。他们有严重的创伤或手术史。另外4例患者无下颌后缩或HO累及面部或咀嚼肌，张口度正常。CT检查可以显示翼肌HO，这可能导致老年FOP患者的下颌限制和下颌后缩。(Oral口腔外科医学口腔病理学口腔放射学Endod 2011;111：499-502）
Objective. The aim of this study was the evaluation by using computerized tomography (CT) of craniofacial abnormalities in fibrodysplasia ossificans progressiva (FOP) patients regarding jaw restriction and retrognathia.Study design. Seven FOP patients were evaluated retrospectively in this observational study. Inclusion criteria were detection of ACVR1 gene mutation and complete craniofacial CT examination. The age of jaw restriction and presence of retrognathia were clinically determined. The features analyzed were skull base structures and heterotopic ossification (HO).Results. Of this group (age range 4-23 years), the 3 oldest patients presented with jaw restriction and retrognathia as well as displayed elongation of the lateral pterygoid plate with HO of the pterygoid muscles that reached the medial surface of the right mandibular ramus. They had significant history of trauma or surgery. The other 4 patients did not have retrognathia or HO involving the facial or masticatory muscles, and the mouth opening was normal.Conclusions. CT evaluation can reveal HO of the pterygoid muscles that probably may cause jaw restriction and retrognathia in older FOP patients. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;111:499-502)