Baseline and stress-induced corticosterone levels are heritable and genetically correlated in a barn owl population
Baseline and stress-induced corticosterone levels are heritable and genetically correlated in a barn owl population
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DOI：
10.1038/s41437-019-0203-5
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发表时间：
2019-09-01
期刊：
影响因子：
3.8
通讯作者：
Roulin, Alexandre
中科院分区：
文献类型：
--
作者：
Beziers, Paul;San-Jose, Luis M.;Roulin, Alexandre
下丘脑-垂体-肾上腺（HPA）轴负责调节皮质酮，皮质酮是一种在能量分配和生理应激中起重要作用的激素。作为生物体挑战和压力的持续来源，环境促进了生理适应的进化，并导致个体、种群和物种内部或之间皮质酮谱的巨大变化。为了通过自然选择进化，皮质酮水平不仅取决于施加在它们身上的选择强度，而且还取决于皮质酮调节的遗传程度。然而，在野生种群皮质酮配置文件的遗传力仍然知之甚少。在这项研究中，我们估计的遗传基线和应激诱导皮质酮水平仓鸮（草鸮）雏鸟8年的数据，使用多变量动物模型的基础上的行为谱系。我们发现，基线和应激诱导的皮质酮水平具有很强的遗传相关性（r = 0.68-0.80），应激诱导的皮质酮水平的遗传力（h（2）= 0.24-0.33）是中等的，与基线皮质酮水平的遗传力（h（2）= 0.19-0.30）相似。这些研究结果表明，压力诱导的皮质酮和基线水平的调节演变时，选择行为具有相同的强度在这两个特征，相反，以前的研究，基线和压力诱导的水平的演变是相互依赖的谷仓猫头鹰，因为它们可能是强烈的遗传相关性。
The hypothalamic-pituitary-adrenal (HPA) axis is responsible for the regulation of corticosterone, a hormone that is essential in the mediation of energy allocation and physiological stress. As a continuous source of challenge and stress for organisms, the environment has promoted the evolution of physiological adaptations and led to a great variation in corticosterone profiles within or among individuals, populations and species. In order to evolve via natural selection, corticosterone levels do not only depend on the strength of selection exerted on them, but also on the extent to which the regulation of corticosterone is heritable. Nevertheless, the heritability of corticosterone profiles in wild populations is still poorly understood. In this study, we estimated the heritability of baseline and stress-induced corticosterone levels in barn owl (Tyto alba) nestlings from 8 years of data, using a multivariate animal model based on a behavioural pedigree. We found that baseline and stress-induced corticosterone levels are strongly genetically correlated (r = 0.68-0.80) and that the heritability of stress-induced corticosterone levels (h(2) = 0.24-0.33) was moderate and similar to the heritability of baseline corticosterone levels (h(2) = 0.19-0.30). These findings suggest that the regulation of stress-induced corticosterone and baseline levels evolves at a similar pace when selection acts with the same intensity on both traits and that contrary to previous studies, the evolution of baseline and stress-induced level is interdependent in barn owls, as they may be strongly genetically correlated.