Brain regional serotonin synthesis following adaptation to repeated restraint.
Brain regional serotonin synthesis following adaptation to repeated restraint.
复制标题
适应反复约束后大脑区域血清素的合成。
作者：
D. Haleem;T. Parveen
一个单一的2小时的情节束缚应激减少大鼠的摄食量和生长速度。这些赤字没有观察到5个约束期后，每天2小时，这表明发生了适应。急性挑战与2小时的限制增加5-羟色胺（5-HT）的合成率在皮质，下丘脑，中脑和后脑先前不受限制的大鼠，但不适应5天的2小时每天限制。海马和纹状体5-HT的合成没有显着增加2小时的限制在以前不受限制的大鼠，但增加和减少，分别在大鼠暴露于5个2小时的日常限制，当他们被限制在第六天。研究结果表明，5-羟色胺的重要作用，特别是在海马，在适应压力。
A single 2 h episode of restraint stress decreased food intake and growth rate of rats. These deficits were not observed after five restraint periods of 2 h a day, suggesting that adaptation occurred. An acute challenge with 2 h restraint increased 5-hydroxytryptamine (5-HT) synthesis rate in the cortex, hypothalamus, midbrain and hindbrain of previously unrestrained rats, but not those adapted to 5 days of 2 h daily restraint. Hippocampal and striatal 5-HT synthesis was not increased significantly by 2 h restraint in previously unrestrained rats but was increased and decreased, respectively, in rats exposed to five 2 h daily restraints, when they were restrained on the sixth day. The findings suggest an important role of 5-HT particularly in the hippocampus, in adaptation to stress.