Erythrocyte selenium-glutathione peroxidase activity is lower in patients with coronary atherosclerosis.
Erythrocyte selenium-glutathione peroxidase activity is lower in patients with coronary atherosclerosis.
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冠状动脉粥样硬化患者的红细胞硒谷胱甘肽过氧化物酶活性较低。
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
E. Semiz
中科院分区：
文献类型：
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作者：
Aysenur Yegin;Haluk Yegin;Y. Alicigüzel;N. Değer;E. Semiz
为进一步了解红细胞抗氧化系统在动脉粥样硬化发生发展中的作用，测定了37例经冠状动脉造影证实的冠状动脉狭窄患者和15例冠状动脉造影正常者红细胞内酶活性和红细胞硒水平。在一项初步研究中，葡萄糖-6-磷酸脱氢酶（G6 PD），谷胱甘肽还原酶（GR）和硒依赖性谷胱甘肽过氧化物酶（Se-GPx）的酶活性进行了测量，在血管造影术前从患者的静脉和动脉血样本。初步研究的数据显示，患者中只有Se-GPx降低，这使我们专注于Se-GPx和Se水平，以确定这些变量的变化。我们的研究结果表明，有一个减少，在两个硒GPx活性和硒水平在红细胞平行的冠状动脉疾病的严重程度增加。得出的结论是，这些参数可能被用作评估疾病严重程度的决定因素。
To obtain further insight into the role of erythrocyte antioxidant systems in the development of atherosclerosis, intraerythrocyte enzyme activities and selenium levels in erythrocytes were determined in 37 patients with angiographically proved coronary artery stenosis and 15 subjects with normal coronary angiograms as controls. In a preliminary study, the enzymatic activities of glucose-6-phosphate dehydrogenase (G6PD), glutathione reductase (GR) and selenium-dependent glutathione peroxidase (Se-GPx) were measured in both venous and arterial blood samples obtained from patients before angiography. The data of the preliminary study, which showed that only the Se-GPx decreased in the patients, led us to concentrate on the Se-GPx and Se levels to determine the changes in these variables. Our results showed that there was a decrease in both the activity of Se-GPx and Se levels in erythrocytes parallel to the increase in the severity of coronary artery disease. It was concluded that these parameters might be used as determinants in the assessment of the severity of the disease.
影响因子：
4.7
作者：
D. Hensrud;D. Heimburger;J. Chen;B. Parpia
通讯作者：
D. Hensrud;D. Heimburger;J. Chen;B. Parpia