Structural Evolution of PCL during Melt Extrusion 3D Printing
Structural Evolution of PCL during Melt Extrusion 3D Printing
复制标题
DOI：
10.1002/mame.201700494
复制
发表时间：
2018-02-01
影响因子：
3.9
通讯作者：
Bartolo, Paulo
中科院分区：
文献类型：
--
作者：
Liu, Fengyuan;Vyas, Cian;Bartolo, Paulo
螺杆辅助材料挤出技术是一种新型的组织工程支架材料制备技术，具有良好的多尺度微观结构特征和可定制的力学性能。在这项研究中，原位时间分辨同步辐射衍射被用来探测基于挤出的聚己内酯（PCL）长丝的3D打印。时间分辨X射线衍射测量揭示了PCL在3D打印过程中整体晶体结构演变的进展。特别是，在原位实验观察提供了强有力的证据PCL晶体的发展过程中的挤出驱动的过程中的强方向性。结果还显示了通过基于熔融挤出的3D打印实现各向异性结构特征的证据，这是模仿自然界中生物材料（如人体组织）的各向异性特性和分层结构的关键发展。
Screw-assisted material extrusion technique is developed for tissue engineering applications to produce scaffolds with well-defined multiscale microstructural features and tailorable mechanical properties. In this study, in situ time-resolved synchrotron diffraction is employed to probe extrusion-based 3D printing of polycaprolactone (PCL) filaments. Time-resolved X-ray diffraction measurements reveals the progress of overall crystalline structural evolution of PCL during 3D printing. Particularly, in situ experimental observations provide strong evidence for the development of strong directionality of PCL crystals during the extrusion driven process. Results also show the evidence for the realization of anisotropic structural features through the melt extrusion-based 3D printing, which is a key development toward mimicking the anisotropic properties and hierarchical structures of biological materials in nature, such as human tissues.