EFFECT OF 14-MEMBERED RING MACROLIDE THERAPY ON CHRONIC RESPIRATORY-TRACT INFECTIONS AND POLYMORPHONUCLEAR LEUKOCYTE ACTIVITY
EFFECT OF 14-MEMBERED RING MACROLIDE THERAPY ON CHRONIC RESPIRATORY-TRACT INFECTIONS AND POLYMORPHONUCLEAR LEUKOCYTE ACTIVITY
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DOI：
10.2169/internalmedicine.34.469
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发表时间：
1995-06-01
影响因子：
1.2
通讯作者：
CHIDA, K
中科院分区：
文献类型：
--
作者：
SHIRAI, T;SATO, A;CHIDA, K
我们研究了14元环大环内酯类药物长期给药治疗弥漫性泛细支气管炎（DPB）（34例）和支气管扩张（BE）（40例）患者的疗效。评价了红霉素（400或600 mg）、罗红霉素（150或300 mg）或克拉霉素（200或400 mg）每日口服给药至少2个月。红霉素、罗红霉素和克拉霉素治疗DPB的有效性分别为19/24（79%）、67（86%）和2/3（67%）。这些药物对BE的疗效超过50%。我们确定了这些大环内酯类药物对从健康志愿者中获得的多形核白细胞（PMN）活性的影响。这些14元环大环内酯类药物与交沙霉素（一种16元环大环内酯类药物，以前发现对治疗DPB无效）的作用之间没有显著差异。因此，14元环大环内酯类药物治疗DPB的有效性似乎取决于PMN活性改变以外的机制。
We studied the efficacy of the long-term administration of 14-membered ring macrolides in treating patients with diffuse panbronchiolitis (DPB) (34 patients) and bronchiectasis (BE) (40 patients). Oral administration of erythromycin (400 or 600 mg), roxithromycin (150 or 300 mg) or clarithromycin (200 or 400 mg) given daily for at least 2 months, was evaluated. The efficacy of erythromycin, roxithromycin, and clarithromycin in DPB was 19/24 (79%), 6/7 (86%), and 2/3 (67%), respectively. Efficacy of these agents in BE exceeded 50%. We determined the effect of these macrolides on the activity of polymorphonuclear leukocytes (PMNs) obtained from healthy volunteers. There were no significant differences between the effects of these 14-membered ring macrolides and josamycin, a 16-membered ring macrolide which was previously found to be ineffective in treating DPB. Thus, the effectiveness of the 14-membered ring macrolides in treating DPB appears to depend on mechanism(s) other than alterations in PMN activity.