Cellular functions of plasma membrane estrogen receptors
Cellular functions of plasma membrane estrogen receptors
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DOI：
10.1016/s0039-128x(01)00179-9
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发表时间：
2002-05-01
期刊：
影响因子：
2.7
通讯作者：
Levin, ER
中科院分区：
文献类型：
--
作者：
Levin, ER
强有力的证据表明，目前存在的质膜雌激素受体（ER）的存在和重要性，在各种细胞的类固醇作用的目标。当雌二醇（E2）与细胞表面蛋白结合时，信号转导的启动会触发下游信号级联反应，从而发挥重要功能。这些功能包括细胞生长和存活、迁移和新血管形成。在某些情况下，这些作用是由基因转录的起始引起的，通过来自膜的信号传导上调。膜ER可能来源于产生核受体的相同基因和转录本。在膜中，ER似乎主要定位于质膜的离散域，称为小窝，但这一小池的ER易位到这个网站的机制目前尚不清楚。在小窝，与信号分子的串扰促进E2/ER细胞的生物学作用。这两者都包括通过G蛋白活化直接刺激信号传导，以及表皮生长因子受体（EGFR）的交叉活化。这篇综述文章强调了一些重要的进展，了解细胞生物学的雌激素作用，从膜发出。(C)2002年爱思唯尔科学公司All rights reserved.
Strong evidence now exists for the presence and importance of plasma membrane estrogen receptors (ER) in a variety of cells that are targets for steroid action. When estradiol (E2) binds cell surface proteins, the initiation of signal transduction triggers downstream signaling cascades that contribute to important functions. These functions include cell growth and survival, migration, and new blood vessel formation. In some instances these effects result from the initiation of gene transcription, upregulated through signaling from the membrane. The membrane ER probably originates from the same gene and transcript that produces the nuclear receptor. In the membrane, ER appear to localize mainly to discrete domains of the plasma membrane, known as caveolae, but the mechanisms by which this small pool of ER translocates to this site are currently unknown. At the caveolae, a cross talk with signaling molecules facilitates E2/ER cell biologic actions. This both includes direct stimulation of signaling via G protein activation, and a cross-activation of the epidermal growth factor receptor (EGFR). This review article highlights some of the important advances in understanding the cell biology of estrogen action that emanates from the membrane. (C) 2002 Elsevier Science Inc. All rights reserved.