Vascular biology of uterine fibroids: connecting fibroids and vascular disorders.
Vascular biology of uterine fibroids: connecting fibroids and vascular disorders.
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DOI：
10.1530/rep-21-0087
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发表时间：
2021-07-08
期刊：
影响因子：
--
通讯作者：
Borahay MA
中科院分区：
文献类型：
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作者：
Kirschen GW;AlAshqar A;Miyashita-Ishiwata M;Reschke L;El Sabeh M;Borahay MA
子宫肌瘤是由子宫肌层平滑肌细胞增殖引起的良性肿瘤，可导致腹痛、便秘、尿潴留和不孕等症状。虽然传统上被认为是子宫固有的疾病过程，但越来越多的证据表明，子宫肌瘤的生长可能与全身血管系统有关，尽管细胞内在因素在其开始时肯定是主要的重要因素。肌瘤与原发性高血压、子痫前期以及动脉粥样硬化有关，其原因正变得越来越明确。诸如肾素-血管紧张素-醛固酮系统、雌激素和内皮功能障碍等因素都可能在肌瘤的发病机制中发挥作用。在这篇综述中，我们展示了将肌瘤重新定义为一种系统性血管疾病的框架，并讨论了针对血管系统的药物和其他干预措施如何有助于肌瘤的新治疗。
Fibroids are benign tumors caused by proliferation of myometrial smooth muscle cells in the uterus that can lead to symptoms such as abdominal pain, constipation, urinary retention, and infertility. While traditionally thought of as a disease process intrinsic to the uterus, accumulating evidence suggests that fibroid growth may be linked with the systemic vasculature system, although cell-intrinsic factors are certainly of principal importance in their inception. Fibroids are associated with essential hypertension and preeclampsia, as well as atherosclerosis, for reasons that are becoming increasingly elucidated. Factors such as the renin-angiotensin-aldosterone system, estrogen, and endothelial dysfunction all likely play a role in fibroid pathogenesis. In this review, we lay out a framework for reconceptualizing fibroids as a systemic vascular disorder, and discuss how pharmaceutical agents and other interventions targeting the vasculature may aid in novel treatment of fibroids.