A new model describing the swelling and drug release kinetics from hydroxypropyl methylcellulose tablets.
A new model describing the swelling and drug release kinetics from hydroxypropyl methylcellulose tablets.
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DOI：
10.1021/js9802291
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发表时间：
1999
影响因子：
3.8
通讯作者：
J. Siepmann;J. Siepmann;Kairali Podual;M. Sriwongjanya;N. Peppas;R. Bodmeier
中科院分区：
文献类型：
--
作者：
J. Siepmann;J. Siepmann;Kairali Podual;M. Sriwongjanya;N. Peppas;R. Bodmeier
提出了一种新的羟丙基甲基纤维素（HPMC）片剂水分传输和药物释放的数学模型。Fick扩散第二定律用于描述药物/聚合物/水三组分体系的传质过程。提供了相应的偏微分方程组的数值解，考虑圆柱形片剂内的轴向和径向扩散。它示出的扩散系数强烈依赖于水的浓度（参数量化这种依赖性已被确定）。溶胀的设备被认为是使用移动边界条件，而溶解过程被忽略。实验证明了该理论的适用性。新模型的实际好处是计算所需的形状和尺寸的HPMC片剂，以实现所需的释放曲线。
A novel mathematical model for the water transport into and drug release from hydroxypropyl methylcellulose (HPMC) tablets is presented. Fick's second law of diffusion is used to describe the mass transfer processes in the three-component system drug/polymer/water. Numerical solutions of the respective set of partial differential equations are provided, considering axial and radial diffusion within cylindrical tablets. It is shown that the diffusion coefficients strongly depend on the water concentration (parameters quantifying this dependence have been determined). Swelling of the device is considered using moving boundary conditions, whereas dissolution processes are neglected. Experiments proved the applicability of the theory. The practical benefit of the new model is to calculate the required shape and dimensions of HPMC tablets to achieve a desired release profile.