Omega-3 and Omega-6 Fatty Acids and Type 2 Diabetes
Omega-3 and Omega-6 Fatty Acids and Type 2 Diabetes
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DOI：
10.1007/s11892-012-0362-8
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发表时间：
2013-04-01
影响因子：
4.2
通讯作者：
Schulze, Matthias B.
中科院分区：
文献类型：
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作者：
Jeppesen, Charlotte;Schiller, Katja;Schulze, Matthias B.
考虑到多不饱和脂肪酸在心血管疾病相关的几个病理生理过程中的潜在作用，它们在糖尿病的营养治疗中特别受关注。omega-3和omega-6脂肪酸都有利于改善健康人和2型糖尿病患者的脂质谱：补充omega-3脂肪酸可降低甘油三酯和低密度脂蛋白胆固醇。然而，它们也可能增加低密度脂蛋白胆固醇。最新证据显示，Omega-3脂肪酸与死亡率和心血管疾病无关。同样，葡萄糖控制和高血压，以及微血管并发症的风险似乎不受omega-3补充剂的影响。大多数研究主要涉及2型糖尿病患者，未来的研究需要关注1型糖尿病患者。此外，omega-6脂肪酸的作用在很大程度上仍然未知。
Polyunsaturated fatty acids are of particular interest in the nutritional therapy for diabetes, given their potential role in several pathophysiological processes related to cardiovascular disease. Both omega-3 and omega-6 fatty acids are beneficial for improving lipid profiles in healthy individuals and among type 2 diabetic patients: Supplementation with omega-3 fatty acids lowers triglycerides and VLDL-cholesterol. However, they might also increase LDL-cholesterol. Omega-3 fatty acids are, from the latest evidence, not related to mortality and cardiovascular disease. Similarly, glucose control and hypertension, as well as risk of microvascular complications, seem unaffected by omega-3 supplementation. Most studies involved mainly patients with type 2 diabetes, and future research needs to focus on the type 1 diabetic patient. Also, the role of omega-6 fatty acids remains largely unknown.