2,3,4-trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran, a novel antioxidant, from Penicillium citrinum F5
2,3,4-trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran, a novel antioxidant, from Penicillium citrinum F5
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DOI：
10.1021/np010605o
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发表时间：
2002-05-01
影响因子：
5.1
通讯作者：
Tsai, YC
中科院分区：
文献类型：
--
作者：
Chen, CH;Shaw, CY;Tsai, YC
对桔青霉F5的发酵液进行生物分离，分离得到一种新的抗氧化剂2，3，4-trimethyl-5，7-dihydroxy-2，3-dihydrobenzofuran(1)和龙胆酸(2)，并根据光谱数据确定了它们的结构。在1，1-二苯基-胡椒基-肼(DPPH)测定体系中，化合物1和2具有清除自由基活性，IC20值分别为10.39和4.26微米。
Bioassy-directed fractionation of a culture broth of Penicillium citrinum F5 led to the isolation of a novel antioxidant 2,3,4-trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran (1), together with gentisic acid (2), and their structures were determined on the basis of spectroscopic data. In the 1,1-diphonyl-pieryl-hydrazyl (DPPH) assay system, compounds 1 and 2 showed free radical scavenging activity with IC20 values of 10.39 and 4.26 muM, respectively.