Iridium-Catalyzed [4+3] Cyclization of ortho-Tosylaminophenyl-Substituted para-Quinone Methides with Vinylic Oxiranes/Vinyl Aziridines
Iridium-Catalyzed [4+3] Cyclization of ortho-Tosylaminophenyl-Substituted para-Quinone Methides with Vinylic Oxiranes/Vinyl Aziridines
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铱催化的 [4 3] 邻甲苯磺酰氨基苯基取代的对醌甲基化物与乙烯基环氧乙烷/乙烯基氮丙啶的环化
DOI：
10.1002/ajoc.202100296
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发表时间：
2021
影响因子：
2.7
通讯作者：
Hu Lihong
中科院分区：
文献类型：
--
作者：
Wang Junwei;Zhao Lin;Li Caihong;Zhao Lei;Zhao Kun;Hu Yang;Hu Lihong
研究了铱催化的对甲苯磺酰胺基苯基取代的对苯醌甲基化物与乙烯基环氧乙烷或乙烯基氮杂环丙烷的[4+3]环化反应。在[Ir（cod）Cl] 2和合适的碱的存在下，这种前所未有的级联反应以良好的产率（高达97%）和高非对映选择性（dr>20：1）容易地发生，为合成有价值的七元杂环框架提供了高效的合成方法。
An Iridium‐catalyzed [4+3] cyclization ofortho‐tosylaminophenyl‐substitutedpara‐quinone methides with vinylic oxiranes or vinyl aziridines has been successfully developed. In the presence of [Ir(cod)Cl]2and a suitable base, this unprecedented cascade reaction occurs readily in good yield (up to 97%) and high diastereoselectivity (dr>20 : 1), providing a highly efficient synthetic approach to synthetically valuable seven‐membered heterocyclic frameworks.