Effect of Vitamin B12 and folic acid supplementation on neuropsychiatric symptoms and immune response in HIV-positive patients
Effect of Vitamin B12 and folic acid supplementation on neuropsychiatric symptoms and immune response in HIV-positive patients
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DOI：
10.4103/0976-3147.182774
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发表时间：
2016-07-01
影响因子：
1.4
通讯作者：
Acharya, Sahana D.
中科院分区：
文献类型：
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作者：
Adhikari, Prabha M.;Chowta, Mukta N.;Acharya, Sahana D.
背景：hiv感染者中B12和叶酸等微量营养素缺乏的比例较高。目的：我们进行了一项研究，研究补充维生素B12和叶酸对hiv阳性患者的神经精神表现、CD4计数和人体测量的影响。材料与方法：将HIV合并结核患者、HIV合并神经精神症状患者、HIV合并无症状患者三组，每组50例。进行基线和随访CD4计数、人体测量、神经精神评估、维生素B12和叶酸估计。结果：叶酸缺乏症发生率为：组27.1%，组31.9%，组23.4%。维生素B12缺乏症发生率分别为8.16%、6.12%和4.16%。有神经精神表现的HIV患者的平均迷你精神得分最低。在补充维生素后，人体测量值、MMSE和汉密尔顿抑郁评分在所有三组中都有所改善，而汉密尔顿焦虑评分仅在第三组有所改善。在补充维生素后，I组和II组的CD4计数也有所改善。结论：叶酸缺乏症在神经精神病患者中最为严重。大多数叶酸缺乏的人在补充叶酸后，他们的神经精神评估得分和CD4计数都有所改善。
Background: Micronutrients such as B12 and folic acid deficiencies are found in higher number in HIV-infected patients. Objective: We conducted a study to examine the effect of Vitamin B12 and folic acid supplementation on neuropsychiatric manifestations, CD4 count, and anthropometric measurements in HIV-positive patients. Materials and Methods: Three different groups of HIV patients, namely, HIV patients with tuberculosis, HIV patients with neuropsychiatric manifestations, and asymptomatic HIV patients with 50 patients in each group were included in the study. Baseline and follow-up CD4 count, anthropometric measurements, neuropsychiatric assessments, Vitamin B12, and folic acid estimation were done. Results: The prevalence of folic acid deficiency was 27.1% in Group I, 31.9% in Group II, and 23.4% in Group III. The prevalence of Vitamin B12 deficiency was 8.16% in Group I, 6.12% in Group II, and 4.16% in Group III. HIV patients with neuropsychiatric manifestations were noted to have the lowest mean mini-mental score. After the supplementation of vitamins, anthropometric measurements, MMSE as well as Hamilton depression scores, improved in all the three groups whereas Hamilton anxiety scores improved only in Group III. The CD4 count also improved in Groups I and II after the supplementation of vitamins. Conclusion: Folic acid deficiency was highest among neuropsychiatric patients. The majority of people who had a folic acid deficiency have shown improvement in their neuropsychiatric assessment scores as well as CD4 count after its supplementation.