Focal Subcortical Biophysical Abnormalities in Patients Diagnosed With Type 2 Diabetes and Depression
Focal Subcortical Biophysical Abnormalities in Patients Diagnosed With Type 2 Diabetes and Depression
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DOI：
10.1001/archgenpsychiatry.2008.548
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发表时间：
2009-03-01
影响因子：
--
通讯作者：
Hellemann, Gerhard
中科院分区：
文献类型：
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作者：
Kumar, Anand;Gupta, Rakesh;Hellemann, Gerhard
背景：2型糖尿病患者中一直存在重度抑郁症。尽管它的高患病率和临床效果，糖尿病患者抑郁症的神经生物学基板仍然在很大程度上unknown.Objective：研究的生物物理完整性的蛋白质在关键的白色和灰质区域的患者2型糖尿病和抑郁症，以了解抑郁症的病理生理学在diabetes.Design：一个横截面磁化传递研究，采用磁共振成像。检查区域包括前扣带回、胼胝体、额叶和枕叶白色物质、尾状核和豆状核。我们研究了16例诊断为2型糖尿病并抑郁症的患者，22例诊断为糖尿病但无抑郁症的患者（糖尿病对照组）和30名无糖尿病或重度抑郁症的对照组主要结果测量：磁化传递率，衡量灰色和白色物质中蛋白质的生物物理结构。结果：与其他两组相比，糖尿病和抑郁症组的尾状核头部双侧磁化传递率显著降低（P <0.001）。糖尿病对照组的抑郁症糖尿病和健康对照组之间的值。在其他regionsexamined.Conclusions：这些数据表明，有一个重要的皮质下生物物理成分，抑郁症患者2型糖尿病组之间的磁化传递率没有显着差异。这一发现对情绪障碍的神经元回路有着广泛的意义。
Context: Major depressive disorder has been consistently identified in patients with type 2 diabetes. Despite its high prevalence and clinical effect, the neurobiological substrates underlying depression in patients with diabetes remain largely unknown.Objective: To examine the biophysical integrity of proteins in critical white and gray matter regions in patients with type 2 diabetes and major depression to understand the pathophysiology of depression in diabetes.Design: A cross-sectional magnetization transfer study using magnetic resonance imaging. Regions examined included the anterior cingulate, corpus callosum, frontal and occipital white matter, and the caudate and lenticular nuclei.Setting: A tertiary care university hospital.Participants: We studied 16 patients diagnosed with type 2 diabetes and major depression, 22 patients diagnosed with diabetes without depression (diabetic controls), and 30 controls without diabetes or major depression (healthy controls).Main Outcome Measures: Magnetization transfer ratios, a measure of the biophysical structure of proteins in the gray and white matter.Results: Magnetization transfer ratios were significantly lower bilaterally in the head of the caudate nucleus in the group with diabetes and depression compared with the other 2 groups (P < .001). Diabetic controls had values between the depressed diabetic and healthy control groups. There were no significant differences in magnetization transfer ratios between groups in the other regions examined.Conclusions: These data indicate that there is an important subcortical biophysical component to depression in patients with type 2 diabetes. This finding has broad implications for the neuronal circuitry underlying mood disorders.