Association between medication-induced xerostomia and orofacial pain: a systematic review.
Association between medication-induced xerostomia and orofacial pain: a systematic review.
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DOI：
10.3290/j.qi.b4154345
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发表时间：
2023-09-19
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口干症（或口腔干燥）最常见的原因是影响唾液分泌的药物，通常伴有口面疼痛的症状。药物引起的口干可能与客观上可证实的唾液分泌减少有关，也可能无关。在这项研究中，我们试图系统地确定药物引起的口干和口面疼痛之间的关联。使用以下数据库进行系统检索：WoS、PubMed、SCOPUS和MEDLINE。使用的检索词为：口腔干燥或“口干”和药物和（“口腔疼痛”或“口面疼痛”或“颅面疼痛”或“口腔灼热”或“舌痛”）不是干燥症不是癌症。入选标准为药物诱导的口干症和报告的口面部疼痛症状。四名研究人员进行了选择过程和质量评估，两名研究人员进行了数据提取。纳入了7项研究，共计1，029例患者。这些研究在2009年至2022年期间进行，包括横断面研究、病例对照研究和一项随机交叉试验。这些研究共有1029名参与者。所有研究均包括男性和女性参与者，其平均年龄从43岁到100岁不等。药物引起的口干和口面部疼痛之间存在正相关。我们发现唾液流量测量（唾液分泌不足）和药物使用之间没有关联。未来的研究应侧重于唾液流量测量、药物性口干的标准化评估以及将伴随的口面部疼痛诊断纳入病史中，以提供更高水平的证据来建立药物性口腔健康损害的可靠预测因子，以促进临床预防和管理。
Xerostomia, (or oral dryness), is most commonly caused by medications that affect saliva secretion and is often accompanied by symptoms of orofacial pain. Medication-induced xerostomia may or may not be associated with objectively demonstrable hyposalivation. In this study, we attempt to systematically identify an association between medication-induced xerostomia and orofacial pain. A systematic search was conducted using the following databases: WoS, PubMed, SCOPUS, and MEDLINE. The search terms used were: xerostomia OR “dry mouth” AND medication AND (“oral pain” OR “orofacial pain” OR “craniofacial pain” OR “burning mouth” OR “glossodynia”) NOT Sjögren’s NOT cancer. Inclusion criteria were medication-induced xerostomia and reported symptoms of orofacial pain. Four researchers performed the selection process and quality assessment and two researchers conducted data extraction. Seven studies with a total of 1,029 patients were included. These studies were conducted between 2009 – 2022 and consisted of cross-sectional studies, case-control studies, and one randomized crossover trial. The studies consisted of a total of 1029 participants. All studies included male and female participants whose mean ages ranged from 43 to 100 years. A positive association was found between medication-induced xerostomia and orofacial pain. We found no associations between salivary flow measurements (hyposalivation) and medication use. Future research should focus on saliva flow measurements, standardized assessment of medication-induced xerostomia as well as the inclusion of accompanying orofacial pain diagnosis in the medical history to allow for higher level of evidence in establishing reliable predictors of medication-induced oral health damage to facilitate clinical prevention and management.
DOI：
10.3390/ijerph192113776
发表时间：
2022-10-23
影响因子：
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作者：
Michalak, Piotr;Polak-Szlosarczyk, Paulina;Dyduch-Dudek, Wioletta;Kesek, Barbara;Zarzecka-Francica, Elzbieta;Styrna, Maria;Czekaj, Lukasz;Zarzecka, Joanna
通讯作者：
Zarzecka, Joanna