Inhibitory effect of immunoglobulin e production by jin-deuk-chal (Siegesbeckia orientalis)
Inhibitory effect of immunoglobulin e production by jin-deuk-chal (Siegesbeckia orientalis)
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DOI：
10.1081/iph-100108601
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发表时间：
2001-01-01
影响因子：
3.3
通讯作者：
Kim, HM
中科院分区：
文献类型：
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作者：
Hwang, WJ;Park, EJ;Kim, HM
免疫球蛋白（Ig） E水平升高与立即型过敏反应有关。jin - dek -chal是Siegesbeckia orientalis (SO) sL的全株植物。明矾蛋白抗原少量免疫小鼠可使血浆总IgE增加数倍，其中大部分是免疫抗原特异性的。在本研究中，我们研究了Siegesbeckia orientalis （SO）对IgE产生的影响。SO抑制抗原诱导的血浆IgE水平。研究了SO对小鼠全脾细胞白细胞介素（IL）4依赖性IgE反应的影响。脂多糖（LPS）刺激的全脾细胞产生IL-4依赖性IgE被SO抑制。此外，我们使用U266B1人携带IgE的B细胞，我们发现SO抑制LPS + IL-4激活的IgE的产生。这些结果表明，SO通过抑制B细胞的IgE产生而具有抗过敏活性。
Elevated levels of immunoglobulin (Ig) E are associated with immediate-type allergic reactions. Jin-deuk-chal is the whole plant of Siegesbeckia orientalis (SO) sL. Immunization of mice with small amounts of protein antigens on alum results in several fold increases in total plasma IgE, much of it specific for the immunizing antigen. In the present study, we investigated the effect of Siegesbeckia orientalis (SO) on IgE production. SO inhibited the plasma levels of IgE induced by antigens. The effects of SO on the interleukin (IL)4-dependent IgE response by mouse whole spleen cells were studied. IL-4 dependent IgE production of lipopolysaccharide (LPS)-stimulated whole spleen cells was inhibited by SO. In addition, using U266B1 human IgE-bearing B cells, we found that SO inhibited the production of IgE activated by LPS plus IL-4. These results suggest that SO have antiallergic activity by inhibition of IgE production from B cells.