Perlecan functions in chondrogenesis: Insights from in vitro and in vivo models
Perlecan functions in chondrogenesis: Insights from in vitro and in vivo models
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DOI：
10.1159/000075029
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发表时间：
2004-01-01
影响因子：
2.7
通讯作者：
Carson, DD
中科院分区：
文献类型：
--
作者：
Gomes, RR;Farach-Carson, MC;Carson, DD
Perlecan是一种大的硫酸乙酰肝素蛋白多糖，通常存在于成人和胚胎组织的基膜中。最近的研究表明，Perlecan在软骨发育过程中大量积累，并一直是成人软骨中主要的硫酸肝素蛋白多糖。在脊椎动物中，perlecan突变会导致骨骼缺陷。此外，体外研究表明，Perlecan可以刺激软骨分化的早期阶段，并与软骨生长因子协同促进这一过程。这篇简短的文章将总结这些结果，并提出一个结合了这些遗传学和细胞生物学发现的Perlecan功能模型。版权所有(C)2004 S.Karger AG，巴塞尔。
Perlecan is a large heparan sulfate proteoglycan that is typically found in basal lamina of adult and embryonic tissues. Recent studies have demonstrated that perlecan accumulates impressively during cartilage development and is maintained as the major heparan sulfate proteoglycan of adult cartilage. In vertebrates, perlecan mutations result in skeletal defects. Moreover, in vitro studies indicate that perlecan can stimulate early stages of cartilage differentiation and cooperate with chondrogenic growth factors to promote this process. This short article will summarize these results and propose a model for perlecan function that incorporates these genetic and cell biological findings. Copyright (C) 2004 S. Karger AG, Basel.