Synthesis of an ethidium nucleoside and its acyclic analog
Synthesis of an ethidium nucleoside and its acyclic analog
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DOI：
10.1016/s0040-4039(03)00025-x
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发表时间：
2003-02-17
影响因子：
1.8
通讯作者：
Wagenknecht, HA
中科院分区：
文献类型：
--
作者：
Amann, N;Wagenknecht, HA
保护的乙锭核苷8-（3 '，5'-二-O-苯甲酰基-2 '-脱氧-D-呋喃核糖基）-3-乙酰氨基-5-乙基-6-苯基菲啶鎓（5），8-（3 ′，5 ′-二-O-乙酰基-2 ′-脱氧-D-呋喃核糖基）-3-乙酰氨基-5-乙基-6-苯基-菲啶鎓（6），和无环类似物8-[（3R）-1，合成了3-二羟基-4-基]-乙酰氨基-3-氨基-5-乙基-6-苯基菲啶鎓（3）。基于它们不同的稳定性，只有无环衍生物3似乎适合于寡核苷酸合成。此外，无环乙锭核苷类似物3表现出与未衍生化乙锭（1）相当的吸收和发射性质。(C)2003爱思唯尔科技有限公司版权所有。
The protected ethidium nucleosides 8-(3',5'-di-O-benzoyl-2'-deoxy-D-ribofuranosyl)-3-acetamido-5-ethyl-6-phenylphenanthridinium (5), 8-(3',5'-di-O-acetyl-2'-deoxy-D-ribofuranosyl)-3-acetamido-5-ethyl-6-phenyl-phenanthridinium (6), and the acyclic analog 8-[(3R)-1,3-dihydroxy-4-yl]-acetamido-3-amino-5-ethyl-6-phenyl-phenanthridinium (3) were prepared. Based on to their different stability, only the acyclic derivative 3 seems to be suitable for oligonucleotide synthesis. Furthermore, the acyclic ethidium nucleoside analog 3 exhibits comparable absorption and emission properties of the underivatized ethidium (1). (C) 2003 Elsevier Science Ltd. All rights reserved.