Human essential fatty acid deficiency: treatment by topical application of linoleic acid.
Human essential fatty acid deficiency: treatment by topical application of linoleic acid.
复制标题
人体必需脂肪酸缺乏症：局部应用亚油酸治疗。
DOI：
10.1001/archderm.1977.01640070073010
复制
发表时间：
1977
影响因子：
--
通讯作者：
V. Ziboh
中科院分区：
文献类型：
--
作者：
P. Skolnik;W. Eaglstein;V. Ziboh
一名19岁的男性长期接受无脂静脉高营养液治疗，发生必需脂肪酸（EFA）缺乏症。EFA缺乏症在21天后通过每日局部应用亚油酸至患者皮肤而逆转。随着EFA缺乏综合征的临床改善，皮肤和血清中二十碳三烯酸（20：3，n-9）与二十碳四烯酸（20：4，n-6）的比例降至正常水平。皮肤表现（头皮皮炎、脱发和毛发脱色）通过持续局部应用红花油（含60%至70%亚油酸）逆转。
An essential fatty acid (EFA) deficiency developed in a 19-year-old man who was being maintained on a long-term regimen of fat-free, intravenous hyperalimentation fluids. The EFA deficiency was reversed after 21 days by daily, topical application of linoleic acid to the patient's skin. The ratio of eicosatrienoic acid (20:3, n-9) to eicosatetraenoic acid (20:4, n-6) decreased to normal levels in the skin and serum with clinical improvement of the EFA deficiency syndrome. The cutaneous manifestations (scalp dermatitis, alopecia, and depigmentation of hair) were reversed with continued, topical application of safflower oil, which contains 60% to 70% linoleic acid.