MicroRNAs: Novel regulators of immunity
MicroRNAs: Novel regulators of immunity
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DOI：
10.1016/j.autrev.2009.01.008
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发表时间：
2009-05-01
影响因子：
13.6
通讯作者：
Macino, Giuseppe
中科院分区：
文献类型：
--
作者：
Carissimi, Claudia;Fulci, Valerio;Macino, Giuseppe
MicroRNA（miRNAs）是一类进化上保守的小分子非编码RNA，通过靶向mRNA进行翻译抑制或降解，在转录后水平发挥基因表达的关键调控作用。这些微小的基因表达调节因子已被证明具有独特的组织特异性，发育阶段特异性和疾病特异性模式。这些观察结果表明，miRNA可能是细胞分化和维持组织类型身份的重要参与者。事实上，在过去的几年中，一些研究强调了miRNAs在适应性和先天免疫系统的分化和功能中起着关键作用。本文综述了miRNAs的作用机制，以及miRNAs在造血系统发育和免疫应答中的重要作用。将讨论在自身免疫性疾病领域产生的影响。(C)2009爱思唯尔有限公司版权所有。
MicroRNAs (miRNAs) are a growing class of evolutionarily conserved small non-coding RNAs that act as key regulators of gene expression at post-transcriptional level by targeting mRNAs for translational repression or degradation. These tiny regulators of gene expression have been shown to have unique tissue-specific, developmental stage-specific and disease-specific patterns. These observations suggest that miRNAs might be essential players in cell differentiation and maintenance of tissue type identity. Indeed, during the last years several studies highlighted that miRNAs play a critical role in the differentiation and function of the adaptive and innate immune systems. This review provides an overview of the miRNAs mode of action and of the important and diverse roles of miRNAs in regulating the development of hematopoietic system and in modulating immune responses. The implications arising in the field of autoimmune diseases will be discussed. (C) 2009 Elsevier B.V. All rights reserved.