Cancer recording and mortality in the General Practice Research Database and linked cancer registries
Cancer recording and mortality in the General Practice Research Database and linked cancer registries
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DOI：
10.1002/pds.3374
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发表时间：
2013-02-01
影响因子：
2.6
通讯作者：
Richards, Mike A.
中科院分区：
文献类型：
--
作者：
Boggon, Rachael;van Staa, Tjeerd P.;Richards, Mike A.
目的 大型电子数据集越来越多地用于评估医疗保健服务。本研究的目的是将癌症登记处持有的信息与全科医学研究数据库 (GPRD) 的信息进行比较。方法 从 GPRD 抽取的 101020 名 40 岁以上患者的方便样本构成了主要数据源。该队列源自最初为糖尿病队列研究建立的更大样本。 GPRD 记录与国家癌症数据存储库 (NCDR) 中癌症登记处的记录相关联。然后评估两个数据集之间的一致性。对于仅在一个数据集上记录的病例，从其他数据集（医院事件统计和死亡登记）以及对 GPRD 记录子集的详细分析中寻求验证。结果 GPRD 共记录了 5797 例癌症（不包括非黑色素瘤皮肤癌）。其中，NCDR 也记录了 4830 例（一致率为 83.3%）。在 GPRD 记录但 NCDR 未记录的 976 例病例中，有 528 例也出现在医院记录或死亡证明中。 NCDR 记录但 GPRD 未记录的 341 例病例中，另外两个数据集中记录了 307 例。一致性率因癌症类型而异。癌症登记处记录了更多的肺癌、结直肠癌和胰腺癌患者，而 GPRD 记录了更多的血液癌和黑色素瘤患者。正如预期的那样，GPRD 记录的非黑色素瘤皮肤癌明显增多。随着年龄的增长，一致性下降。结论 尽管一致性水平相当高，但本研究的结果可用于指导更好地记录两个数据集的工作。版权所有 (c) 2012 皇家版权。
Purpose Large electronic datasets are increasingly being used to evaluate healthcare delivery. The aim of this study was to compare information held by cancer registries with that of the General Practice Research Database (GPRD). Methods A convenience sample of 101020 patients aged 40+ years drawn from GPRD formed the primary data source. This cohort was derived from a larger sample originally established for a cohort study of diabetes. GPRD records were linked with those from cancer registries in the National Cancer Data Repository (NCDR). Concordance between the two datasets was then evaluated. For cases recorded only on one dataset, validation was sought from other datasets (Hospital Episode Statistics and death registration) and by detailed analysis of a subset of GPRD records. Results A total of 5797 cancers (excluding non-melanomatous skin cancer) were recorded on GPRD. Of these cases, 4830 were also recorded on NCDR (concordance rate of 83.3%). Of the 976 cases recorded on GPRD but not on NCDR, 528 were present also in the hospital records or death certificates. Of the 341 cases recorded on NCDR but not on GPRD, 307 were recorded in these other two datasets. Rates of concordance varied by cancer type. Cancer registries recorded larger numbers of patients with lung, colorectal, and pancreatic cancers, whereas GPRD recorded more haematological cancers and melanomas. As expected, GPRD recorded significantly more non-melanomatous skin cancer. Concordance decreased with increasing age. Conclusion Although concordance levels were reasonably high, the findings from this study can be used to direct efforts for better recording in both datasets. Copyright (c) 2012 Crown copyright.