Importance of Upper Airway Airflow in the Ventilatory Depression of Laryngeal Origin
Importance of Upper Airway Airflow in the Ventilatory Depression of Laryngeal Origin
复制标题
上呼吸道气流在喉源通气抑制中的重要性
DOI：
10.1203/00006450-198307000-00007
复制
发表时间：
1983
影响因子：
3.6
通讯作者：
A. Noworaj
中科院分区：
文献类型：
--
作者：
J. Mortola;S. Al;A. Noworaj
总结：通过上呼吸道的气流会抑制通气，特别是在新生儿中。这种反射反应可能是由于上气道压力和/或上气道气流的变化。为了研究这两个因素的单独作用，我们研究了四只成年猫和三只新生小猫用戊巴比妥麻醉。动物通过置于颈部下方的气管造口术自主呼吸。位于喉部正下方的第二个插管可以连接到稳定的气流源或加压罐。在输送上气道气流的过程中，潮气量、频率和通气量降低。当施加的静压值与气流输送过程中测得的静压值相似时，未观察到压缩参数的降低。我们的结论是，动态的流量依赖因素所需的净化抑制起源于上气道。
Summary: Flows of air through the upper airway depress ventilation, particularly in newborns. This reflex response can be due to changes in upper airway pressure and/or upper airway airflow. In order to investigate the separate role of these two factors, we have studied four adult cats and three newborn kittens anaesthetized with pentobarbital. The animals were spontaneously breathing through a tracheostomy placed low in the neck. A second cannula located just below the larynx could be connected to a steady airflow source or to a pressurized jar. During the delivery of upper airway airflows, tidal volume, frequency and ventilation were decreased. When static pressures of values similar to those measured during the delivery of the airflows were applied, no depression of the ventilatory parameters was observed. We conclude that dynamic flow dependent factors are required for the ventilatory inhibition originating from the upper airways.
气道感觉剥夺导致阻塞性呼吸暂停的动物模型，尸检发现婴儿猝死综合症。
影响因子：
8
作者：
Abu-Osba,YK;Mathew,OP;Thach,BT
通讯作者：
Thach,BT