Iridoids and sesquiterpenoids of Valeriana stenoptera and their effects on NGF-induced neurite outgrowth in PC12 cells
Iridoids and sesquiterpenoids of Valeriana stenoptera and their effects on NGF-induced neurite outgrowth in PC12 cells
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DOI：
10.1016/j.phytochem.2015.08.015
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发表时间：
2015-10-01
期刊：
影响因子：
3.8
通讯作者：
Hu, Jiang-Miao
中科院分区：
文献类型：
--
作者：
Dong, Fa-Wu;Wu, Zhi-Kun;Hu, Jiang-Miao
从缬草的干燥材料中分离出 21 种化合物（9 种环烯醚萜类化合物和 12 种倍半萜类化合物），其中包括 10 种以前未知的化合物（5 种环烯醚萜类化合物和 5 种倍半萜类化合物）。在广泛的光谱分析的基础上确定了结构，并通过 X 射线晶体学数据进一步证实了 13-羟基广藿香醇 A 的相对立体化学。对所有分离株对嗜铬细胞瘤 (PC12) 细胞中神经生长因子 (NGF) 介导的神经突生长的影响进行了评估，七种化合物显示出有效的促进作用。 (C) 2015 Elsevier Ltd. 保留所有权利。
Twenty-one compounds (nine iridoids and twelve sesquiterpenoids), including ten previously unknown (five iridoids and five sesquiterpenoids) were isolated from whole dried material of Valeriana stenoptera. Structures were established on the basis of extensive spectroscopic analysis and the relative stereochemistry of 13-hydroxypatchoulol A was further confirmed by X-ray crystallographic data. All isolates were evaluated for their effects on nerve growth factor (NGF)-mediated neurite outgrowth in pheochromocytoma (PC12) cells and seven compounds showed potent promoting effects. (C) 2015 Elsevier Ltd. All rights reserved.