Perfluorooctane sulfonate influences feeding behavior and gut motility via the hypothalamus.
Perfluorooctane sulfonate influences feeding behavior and gut motility via the hypothalamus.
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DOI：
10.3892/ijmm.19.5.733
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发表时间：
2007-05
影响因子：
5.4
通讯作者：
A. Asakawa;M. Toyoshima;M. Fujimiya;Kouji H. Harada;K. Ataka;Kayoko Inoue;A. Koizumi
中科院分区：
文献类型：
--
作者：
A. Asakawa;M. Toyoshima;M. Fujimiya;Kouji H. Harada;K. Ataka;Kayoko Inoue;A. Koizumi
全氟化合物 (PFC) 已在多种产品中用作表面处理剂。全氟辛烷磺酸 (PFOS) 和全氟辛酸 (PFOA) 是环境和人体血液中最常见的两种 PFC。我们研究了 PFOS 和 PFOA 对进食行为的影响。将 PFOS 或 PFOA 注射到小鼠或大鼠的脑室内。给药后，测定食物摄入、胃十二指肠运动、胃排空、下丘脑神经肽的基因表达、c-Fos 表达以及室旁核 (PVN) 中尿皮质素 2 的免疫反应。集中施用 PFOS 和 PFOA 可减少食物摄入量。施用全氟辛烷磺酸会减少胃排空并扰乱胃窦和十二指肠的禁食运动活动。 PFOS的作用增加了下丘脑中尿皮质素2的基因表达以及PVN中尿皮质素2的c-Fos表达和免疫反应。一种集中给药的促肾上腺皮质激素释放因子 2 型受体 (CRFR2) 拮抗剂可阻断 PFOS 引起的厌食症。这些发现表明全氟辛烷磺酸和全氟辛酸影响喂养行为。这种作用是通过激活下丘脑尿皮质素 2 和 CRFR2 以及抑制胃十二指肠运动活动来介导的。这些观察结果表明，PFC 可能在影响人类行为和生理功能方面发挥着重要作用。
Perfluorinated compounds (PFCs) have been employed as surface treatment agents in a variety of products. Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are the two most commonly found PFCs in the environment and human blood. We investigated the effects of PFOS and PFOA on feeding behavior. PFOS or PFOA was administered intracerebroventricularly in mice or rats. Following administration, food intake, gastroduodenal motility, gastric emptying, gene expression of hypothalamic neuropeptides, and c-Fos expression along with immunoreaction for urocortin 2 in the paraventricular nucleus (PVN) were determined. Centrally administered PFOS and PFOA decreased food intake. Administration of PFOS decreased gastric emptying and disrupted the fasted motor activity in the antrum and duodenum. The gene expression of urocortin 2 in the hypothalamus and c-Fos expression and immunoreaction for urocortin 2 in the PVN were increased by the action of PFOS. A centrally administered corticotropin-releasing factor type 2 receptor (CRFR2) antagonist blocked PFOS-induced anorexia. These findings indicate that PFOS and PFOA influence feeding behavior. This effect is mediated via the activation of hypothalamic urocortin 2 and CRFR2, and the suppression of gastroduodenal motor activity. These observations indicate that PFCs may act centrally to influence behavior and physiological functions in humans.