Cochlear microcirculation. Effect of adrenergic agonists on arteriole diameter.
Cochlear microcirculation. Effect of adrenergic agonists on arteriole diameter.
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耳蜗微循环。
DOI：
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
H. Pillsbury
中科院分区：
文献类型：
--
作者：
V. Carrasco;J. Prazma;J. Faber;R. Triana;H. Pillsbury
我们使用活体荧光显微镜结合计算机视频图像处理来检查耳蜗微血管。在蒙古沙鼠的大泡腹侧开放，并在耳蜗的第二圈做了一个小窗。给予异硫氰酸荧光素-葡聚糖后，在X675放大倍率下录像记录放射状小动脉。在多个剂量水平下，随着时间的推移，对重酒石酸去甲肾上腺素（混合α 1/α 2激动剂）、盐酸苯肾上腺素（α 1激动剂）和酒石酸UK 14，304（α 2激动剂）进行小动脉反应的计算机测定。结果与α-肾上腺素能刺激引起的小动脉收缩一致。建立了α 1和α 2受体的存在，并建议耳蜗中α 2受体占优势。
We used intravital fluorescent microscopy coupled with computerized video image processing to examine the cochlear microvasculature. In Mongolian gerbils the bulla was opened ventrally and a small window was made in the second turn of the cochlea. After fluorescein isothiocyanate-dextran administration, the radiating arterioles were video-recorded under X675 magnification. Computer determinations of arteriolar response to norepinephrine bitartrate (mixed alpha 1/alpha 2 agonist), phenylephrine hydrochloride (alpha 1 agonist), and UK 14,304 tartrate (alpha 2 agonist) were made at multiple dose levels over time. Findings were consistent with arteriolar constriction in response to alpha-adrenergic stimulation. The presence of alpha 1 and alpha 2 receptors was established, and a predominance of alpha 2 receptors in the cochlea was suggested.
去甲肾上腺素对大鼠大脑皮层穿通小动脉的影响。
DOI：
10.1152/ajpheart.1984.246.3.h380
发表时间：
1984
期刊：
The American journal of physiology
影响因子：
--
作者：
DaceyJr,RG;Duling,BR
通讯作者：
Duling,BR