ECDYSTERONE INDUCES ACETYLCHOLINESTERASE IN MAMMALIAN BRAIN
ECDYSTERONE INDUCES ACETYLCHOLINESTERASE IN MAMMALIAN BRAIN
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DOI：
10.1016/0742-8413(84)90068-9
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发表时间：
1984-01-01
影响因子：
3.9
通讯作者：
MARTINEZ, AM
中科院分区：
文献类型：
--
作者：
CATALAN, RE;ARAGONES, MD;MARTINEZ, AM
在离体条件下，研究了蜕皮甾酮对未成年和成年大鼠脑乙酰胆碱酯酶（AChE）的影响。蜕皮甾酮引起大鼠脑片乙酰胆碱酯酶活性增加。在未成熟的雄性大鼠中发现了最显著的效果。用纯化的电鳗AChE进行体外测定，结果表明没有影响。放线菌酮或放线菌素D预处理取消蜕皮甾酮对脑AChE的作用。AChE的诱导可能参与蜕皮甾酮的嗜异性作用。
The effects of ecdysterone on brain acetylcholinesterase (AChE) in immature and adult rats of both sexes were studied in in vitro conditions. Ecdysterone produced an increase of AChE in rat brain slices. The most remarkable effect was found in immature male rats. In vitro assay using a purified AChE from electric eel showed no effect. Pretreatment with cycloheximide or actinomycin D abolished the ecdysterone action on brain AChE. Induction of AChE may be involved in the heterophilic action of ecdysterone.