Insights into Oxidation of the Ultrahigh Molecular Weight Polyethylene Artificial Joint Related to Lipid Peroxidation
Insights into Oxidation of the Ultrahigh Molecular Weight Polyethylene Artificial Joint Related to Lipid Peroxidation
复制标题
与脂质过氧化相关的超高分子量聚乙烯人工关节氧化的见解
DOI：
10.1021/acsabm.9b00960
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发表时间：
2020-01-21
影响因子：
4.7
通讯作者：
Li, Zhong-Ming
中科院分区：
文献类型：
--
作者：
Ren, Yue;Wang, Zi-Yang;Li, Zhong-Ming
超高分子量聚乙烯（UHMWPE）轴承的氧化降解是导致其机械性能和磨料耐磨性恶化的主要因素之一，这进一步导致全关节置换失败。滑液的吸收和扩散被认为是UHMWPE轴承氧化的原因。然而，滑液在UHMWPE氧化中的作用仍然难以捉摸。在这项工作中，我们旨在揭示超高分子量聚乙烯关节与角鲨烯（滑液的代表性成分）的氧化机制。掺入角鲨烯的UHMWPE表现为轻微氧化，而掺入角鲨烯的UHMWPE暴露于氧气环境中则表现为严重氧化。角鲨烯在热氧化老化过程中表现为脂质过氧化，氧化产物和氧源自由基显著。脂质过氧化反应有自氧化和热氧化两种途径。角鲨烯自由基从UHMWPE链中提取氢原子，引发UHMWPE人工关节的氧化。这些发现不仅为理解角鲨烯诱导的超高分子量聚乙烯氧化过程提供了依据，而且对开发高抗氧化超高分子量聚乙烯具有指导意义。
Oxidative degradation of ultrahigh molecular weight polyethylene (UHMWPE) bearings is one of the main factors that deteriorates their mechanical properties and abrasive wear resistance, which further results in the failure of total joint replacements. Absorption and diffusion of synovial fluids have been considered as causes of the oxidation of UHMWPE bearings. However, the role of synovial fluids in oxidation of UHMWPE remains elusive. In this work, we aimed to reveal the oxidation mechanism of UHMWPE joints with respect to squalene (a representative component of the synovial fluid). The UHMWPE doped in squalene showed slight oxidation, while severe oxidation was observed when squalene doped UHMWPE was exposed to oxygen atmosphere. Squalene manifested lipid peroxidation with notable oxidation products and oxygen-derived free radicals during thermo-oxidative aging. Lipid peroxidation was deduced to follow two routes including autoxidation and thermal oxidation. The aggressive free radicals of squalene abstracted hydrogen atoms from the UHMWPE chains, initiating the oxidation of UHMWPE artificial joints. These findings not only provide evidence for comprehending the process of squalene-induced UHMWPE oxidation but also are instructive to develop highly oxidative-resistant UHMWPE.