LOW CEREBROSPINAL-FLUID GLUTAMATE IN SCHIZOPHRENIC-PATIENTS AND A NEW HYPOTHESIS ON SCHIZOPHRENIA
LOW CEREBROSPINAL-FLUID GLUTAMATE IN SCHIZOPHRENIC-PATIENTS AND A NEW HYPOTHESIS ON SCHIZOPHRENIA
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DOI：
10.1016/0304-3940(80)90178-0
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发表时间：
1980-01-01
影响因子：
2.5
通讯作者：
HOLZMULLER, B
中科院分区：
文献类型：
--
作者：
KIM, JS;KORNHUBER, HH;HOLZMULLER, B
20例精神分裂症患者脑脊液谷氨酸水平约为正常值的1/2，血清谷氨酸水平无明显变化。谷氨酸含量的降低并不是由于抗精神病药治疗[氟哌啶醇、匹莫齐特、戊氟利多和氟奋乃静]。提示精神分裂症患者谷氨酸能神经元功能障碍或变性。
In the CSF of 20 schizophrenic patients the glutamate level was about 1/2 the normal value; the serum glutamate was not altered. Reduced glutamate content did not appear due to neuroleptic treatment [haloperidol, pimozide, penfluridol and fluphenazine]. A dysfunction or degeneration of glutamatergic neurons in schizophrenia is suggested.