Influence of neuroleptics and benzodiazepines on metabolism of tricyclic antidepressants in man.
Influence of neuroleptics and benzodiazepines on metabolism of tricyclic antidepressants in man.
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精神安定药和苯二氮卓类药物对人体三环类抗抑郁药代谢的影响。
DOI：
10.1176/ajp.131.8.863
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
L. Kirk
中科院分区：
文献类型：
--
作者：
L. Gram;K. Overø;L. Kirk
作者在5例患者中检测了苯二氮卓类药物与去甲替林之间的药代动力学相互作用。每例患者在使用精神抑制剂、地西泮和利血平治疗期间以及在无药物对照期间进行测试。抗精神病药（氟哌啶醇和奋乃静）引起的变化表明14 C-去甲替林代谢的抑制。两种苯二氮卓类药物均未引起14 C-去甲替林药代动力学测量值的显著变化。在大鼠中，14 C-去甲替林的代谢被利氮卓预处理抑制，但仅当剂量为60 mg/kg时。kg.在给予14 C-去甲替林之前的短时间内。
The authors tested the pharmacokinetic interaction between benzodiazepines and nortriptyline in five patients. Each patient was tested during periods of treatment with neuroleptics, diazepam, and chlordiazepoxide, and in a drug-free control period. Neuroleptics (haloperidol and perphenazine) caused changes indicating inhibition of metabolism of 14C-nortriptyline. Neither of the two benzodiazepines caused a significant change in the pharmacokinetic measurements of 14C-nortriptyline. In rats, the metabolism of 14C-nortriptyline was inhibited by pretreatment with chlordiazepoxide, but only when given in a dose of 60 mg./kg. a short time before the administration of 14C-nortriptyline.